Biogenetically patterned synthesis of camptothecin and 20-deoxycamptothecin

被引：31

作者：

Brown, RT ^{[1
]}

Liu, JL ^{[1
]}

Santos, CAM ^{[1
]}

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 06期

关键词：

alkaloids; biogenesis; biomimetic; indole; quinoline; terpene;

D O I：

10.1016/S0040-4039(99)02210-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A biogenetically patterned synthetic route to the monoterpenoid quinoline alkaloids 20-deoxycamptothecin and (+/-)-camptothecin from secologanin and tryptamine via vincoside/strictosidine lactams has now been realized, and hence afforded likely biosynthetic intermediates for testing in vivo. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：859 / 862

页数：4

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