Current perspectives in stem cell therapy for spinal cord repair in humans: a review of work from the past 10 years

被引：2

作者：

Mariano, Eric Domingos ^{[1
,3
]}

Batista, Chary Marquez ^{[1
,3
]}

Alencar Pires Barbosa, Breno Jose ^{[1
]}

Nagahashi Marie, Suely Kazue ^{[1
,3
]}

Teixeira, Manoel Jacobsen ^{[1
]}

Morgalla, Matthias ^{[2
]}

Tatagiba, Marcos ^{[2
]}

Li, Jun ^{[2
]}

Lepski, Guilherme ^{[1
,2
,3
]}

机构：

[1] Univ Sao Paulo, Fac Med, Dept Neurol, Sao Paulo, Brazil

[2] Univ Tubingen, Dept Neurosurg, Tubingen, Germany

[3] Univ Sao Paulo, Lab Biol Mol & Celular, Sao Paulo, Brazil

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2014年 / 72卷 / 06期

关键词：

spinal cord injury; amyotrophic lateral sclerosis; stem cells; stem cell therapy; AMYOTROPHIC-LATERAL-SCLEROSIS; OLFACTORY ENSHEATHING CELLS; MARROW STROMAL CELLS; FOLLOW-UP; INJURY PATIENTS; SCHWANN-CELLS; TRANSPLANTATION; SAFETY; TRIAL; ASTROCYTE;

D O I：

10.1590/0004-282X20140051

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spinal cord injury (SCI) and amyotrophic laterals sclerosis (ALS) are devastating neurological conditions that affect individuals worldwide, significantly reducing quality of life, both for patients and their relatives. Objective: The present review aims to summarize the multiple restorative approaches being developed for spinal cord repair, the use of different stem cell types and the current knowledge regarding stem cell therapy. Method: Review of the literature from the past 10 years of human studies using stem cell transplantation as the main therapy, with or without adjuvant therapies. Conclusion: The current review offers an overview of the state of the art regarding spinal cord restoration, and serves as a starting point for future studies.

引用

页码：451 / 456

页数：6

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