Autoantibody biomarkers in the detection of cancer

被引：43

作者：

Cho-Chung, Yoon S. ^{[1
]}

机构：

[1] NCI, Cellular Biochem Sect, Basic Res Lab, CCR, Bethesda, MD 20892 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2006年 / 1762卷 / 06期

关键词：

autoantibody-based EIA; cancer detection; biomarker; autoantibody ECPKA; cAMP-dependent protein kinase;

D O I：

10.1016/j.bbadis.2006.04.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By definition, tumor biomarkers are selective molecules that can distinguish between patients with cancer and controls. Serum tumor markers have been the most widely used approach for cancer detection. However, the limitations of these markers, which are based on the measurement of tumor antigens, preclude their general use in cancer screening and diagnosis. Here we give an over-view of recent cancer biomarker developments based on the detection of autoantibodies produced against tumor antigens in patients' sera. This new detection method can measure the autoantibodies for a spectrum of tumor antigens in a single assay, with sensitivity and specificity exceeding those obtained using the conventional antigen determination method. Autoantibodies against serum cancer biomarkers offer a novel technology for cancer detection. Published by Elsevier B.V.

引用

页码：587 / 591

页数：5

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