Slicing and dicing viruses: antiviral RNA interference in mammals

被引：90

作者：

Maillard, Pierre V. ^{[1
]}

van der Veen, Annemarthe G. ^{[2
]}

Poirier, Enzo Z. ^{[2
]}

Reis e Sousa, Caetano ^{[2
]}

机构：

[1] UCL, Div Infect & Immun, London, England

[2] Francis Crick Inst, Immunobiol Lab, London, England

来源：

EMBO JOURNAL | 2019年 / 38卷 / 08期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

antiviral immunity; Dicer; double-stranded RNA; interferons; RNA interference; DOUBLE-STRANDED-RNA; INFLUENZA-A-VIRUS; EMBRYONIC STEM-CELLS; HEPATITIS-B-VIRUS; RIG-I; GENE-EXPRESSION; INNATE IMMUNITY; HUMAN DICER; SILENCING SUPPRESSION; 5'-TRIPHOSPHATE RNA;

D O I：

10.15252/embj.2018100941

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell-intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA-based mechanism, for cell-intrinsic immunity to viruses while vertebrates rely on the protein-based interferon (IFN)-driven innate immune system for the same purpose. The RNAi machinery is conserved in vertebrate cells, yet whether antiviral RNAi is still active in mammals and functionally relevant to mammalian antiviral defence is intensely debated. Here, we discuss cellular and viral factors that impact on antiviral RNAi and the contexts in which this system might be at play in mammalian resistance to viral infection.

引用

页数：13

共 185 条

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