The role of Schlafen 11 (SLFN11) as a predictive biomarker for targeting the DNA damage response

被引：41

作者：

Coleman, Niamh ^{[1
,2
,3
]}

Zhang, Bingnan ^{[2
,3
]}

Byers, Lauren A. ^{[2
,3
,4
]}

Yap, Timothy A. ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Phase 1 Program, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Div Canc Med, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

[5] Univ Texas MD Anderson Canc Ctr, Inst Appl Canc Sci, Houston, TX 77030 USA

[6] Univ Texas MD Anderson Canc Ctr, Khalifa Inst Personalized Canc Therapy, Houston, TX 77030 USA

来源：

BRITISH JOURNAL OF CANCER | 2021年 / 124卷 / 05期

关键词：

CANCER;

D O I：

10.1038/s41416-020-01202-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The therapeutic landscape of drugs targeting the DNA damage response (DDR) is rapidly expanding; however, an urgent unmet need remains for validated predictive biomarkers of response. SLFN11 has emerged as a promising predictor of sensitivity to DNA-damaging chemotherapies, and recently, been associated with sensitivity to PARP inhibition. We discuss its use as a predictive biomarker of response for targeting the DDR.

引用

页码：857 / 859

页数：3

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