AgNO3-catalyzed direct C-H arylation of quinolines by oxidative decarboxylation of aromatic carboxylic acids

被引：38

作者：

Yuan, Jin-Wei ^{[1
]}

Yang, Liang-Ru ^{[1
]}

Mao, Pu ^{[1
]}

Qu, Ling-Bo ^{[1
]}

机构：

[1] Henan Univ Technol, Academician Workstn Nat Med Chem Henan Prov, Sch Chem & Chem Engn, Zhengzhou 450001, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 04期

关键词：

CROSS-COUPLING REACTIONS; RH(I)-CATALYZED DIRECT ARYLATION; RADICAL TANDEM CYCLIZATION; N-HETEROARYL HALIDES; SUZUKI-MIYAURA; ARYLBORONIC ACIDS; SUBSTITUTED QUINOLINES; BORONIC ACIDS; EFFICIENT SYNTHESIS; BOND ACTIVATION;

D O I：

10.1039/c6qo00533k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient silver-catalyzed intermolecular decarboxylative arylation of quinolines has been developed using cheap aromatic carboxylic acids as arylating reagents under microwave irradiation. The reaction demonstrates a broad substrate scope and excellent functional group tolerance. This method provided an effective and easy way to synthesize arylated quinoline derivatives. The radical trapping experiments showed that this process involved the radical mechanism.

引用

页码：545 / 554

页数：10

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