WHO Prevention of Blindness Program launched ''VISION 2020" in 1999 to reduce visual impairment and eradicate avoidable blindness by the year 2020. Ethiopia launched the "VISION 2020" initiative in 2002. This systematic review and meta-analysis aimed to present the national prevalence of visual impairment at the end of "VISION 2020". Electronic search was conducted on the PubMed, SCOPUS, EMBASE, Web of Science, CINAHL, Google scholar databases for including articles. This systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Endnote reference manager was used for downloading, organizing, and citing articles. Methodological quality was assessed using the Joanna Briggs Institute (JBI) quality appraisal tool for prevalence studies. Statistical analysis was done using the STATA (TM) software version 14. In this systematic review and meta-analysis, 18 studies involving 14,953 participants were included. The pooled prevalence of visual impairment in Ethiopia after correction for publication bias by Duval and Tweedie's trim and fill analysis was estimated to be 6.24% (95% confidence interval [CI] = [2.66, 9.82]). The pooled prevalence of visual impairment among school children and adults in Ethiopia was 6.13% (95% CI = [4.27, 7.98]) and 19.89% (95% CI = [10.85, 28.93]), respectively. The most common causes of visual impairment in decreasing order of prevalence were refractive error, cataract, trachoma, glaucoma, and corneal opacity. Amblyopia was the cause of visual impairment among school-age child. The prevalence of visual impairment in Ethiopia was still significant at the end of "VISION 2020" program. Therefore, the program of "VISION 2020" should be extended and other large-scale programs were needed to reduce the prevalence of vision impairment in Ethiopia.
