Protoflavones: a class of unusual flavonoids as promising novel anticancer agents

被引：28

作者：

Hunyadi, A. ^{[1
,2
]}

Martins, A. ^{[3
,4
]}

Danko, B. ^{[1
]}

Chang, F. R. ^{[5
,6
,7
]}

Wu, Y. C. ^{[8
,9
,10
]}

机构：

[1] Univ Szeged, Fac Pharm, Inst Pharmacognosy, Szeged, Hungary

[2] Commiss European Communities, COST Act Chem Biol Nat Prod CM0804, B-1049 Brussels, Belgium

[3] Univ Szeged, Fac Med, Dept Med Microbiol & Immunobiol, Szeged, Hungary

[4] Univ Nova Lisboa, Inst Higiene & Med Trop, Unidade Parasitol & Microbiol Med, P-1200 Lisbon, Portugal

[5] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung, Taiwan

[7] Kaohsiung Med Univ, Coll Pharm, R&D Ctr Chinese Herbal Med & New Drugs, Kaohsiung, Taiwan

[8] China Med Univ, Coll Pharm, Sch Pharm, Taichung, Taiwan

[9] China Med Univ Hosp, Nat Med Prod Res Ctr, Taichung, Taiwan

[10] China Med Univ Hosp, Ctr Mol Med, Taichung, Taiwan

来源：

PHYTOCHEMISTRY REVIEWS | 2014年 / 13卷 / 01期

关键词：

Anticancer flavonoids from ferns; Protoflavonoids; Protoapigenone; p-Quinol; Natural product based drug discovery; Cancer; Apoptosis; IN-VITRO; B-RING; PROTOAPIGENONE; CELL; APOPTOSIS; PROTOGENKWANIN; ANTITUMOR; ANALOGS; FERNS; CYCLE;

D O I：

10.1007/s11101-013-9288-2

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Protoflavones represent a less widespread, unique class of natural flavonoids with a non-aromatic B-ring and a hydroxyl group at C-1'. Due to their recently discovered anticancer activity, these compounds have gotten into the focus of biomedical research during the past few years. The present review aims to give a brief summary on the available literature data on this special class of flavonoids, including their occurrence in plants and their bioactivity. A special emphasis is given on the anticancer potential of these compounds. Attempts for the development of certain synthetic/semi-synthetic protoflavone analogs as anticancer drugs, and structure-activity relationships are also discussed.

引用

页码：69 / 77

页数：9

共 45 条

[1] Phenolic constituents of the fern Phegopteris connectilis [J].

Adam, KP .

PHYTOCHEMISTRY, 1999, 52 (05) :929-934

[2] Vitamin nature of flavones [J].

Bentsath, A ;

Rusznyak, S ;

Gyorgyi, AS .

NATURE, 1936, 138 :798-798

[3] Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair [J].

Bolderson, Emma ;

Richard, Derek J. ;

Zhou, Bin-Bing S. ;

Khanna, Kum Kum .

CLINICAL CANCER RESEARCH, 2009, 15 (20) :6314-6320

[4] Protoapigenone, a novel flavonoid, inhibits ovarian cancer cell growth in vitro and in vivo [J].

Chang, Hsueh-Ling ;

Su, Jinu-Huang ;

Yeh, Yao-Tsung ;

Lee, Yi-Chen ;

Chen, Huey-May ;

Wu, Yang-Chang ;

Yuan, Shyng-Shiou F. .

CANCER LETTERS, 2008, 267 (01) :85-95

[5] Protoapigenone, a novel flavonoid, induces apoptosis in human prostate cancer cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase 1/2 [J].

Chang, Hsueh-Ling ;

Wu, Yang-Chang ;

Su, Jinu-Huang ;

Yeh, Yao-Tsung ;

Yuan, Shyng-Shiou F. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 325 (03) :841-849

[6] A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species [J].

Chen, Huei-Mei ;

Chang, Fang-Rong ;

Hsieh, Ya-Ching ;

Cheng, Yu-Jen ;

Hsieh, Kun-Chou ;

Tsai, Lih-Min ;

Lin, An-Shen ;

Wu, Yang-Chang ;

Yuan, Shyng-Shiou .

FREE RADICAL BIOLOGY AND MEDICINE, 2011, 50 (09) :1151-1162

[7] Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferase π [J].

Chen, Wen-Ying ;

Hsieh, Yu-An ;

Tsai, Ching-I ;

Kang, Ya-Fei ;

Chang, Fang-Rong ;

Wu, Yang-Chang ;

Wu, Chin-Chung .

INVESTIGATIONAL NEW DRUGS, 2011, 29 (06) :1347-1359

[8] Fern Plant-Derived Protoapigenone Leads to DNA Damage, Apoptosis, and G2/M Arrest in Lung Cancer Cell Line H1299 [J].

Chiu, Chien-Chih ;

Chang, Hsueh-Wei ;

Chuang, Da-Wei ;

Chang, Fang-Rong ;

Chang, Yu-Ching ;

Cheng, Yu-Shan ;

Tsai, Ming-Tz ;

Chen, Wan-Yu ;

Lee, Su-Shuo ;

Wang, Chih-Kuang ;

Chen, Jeff Yi-Fu ;

Wang, Hui-Min ;

Chen, Chao-Chieh ;

Liu, Yin-Chang ;

Wu, Yang-Chang .

DNA AND CELL BIOLOGY, 2009, 28 (10) :501-506

[9]

Danko B, 2012, ANTICANCER RES, V32, P2863

[10] Flavonoids: Old and new aspects of a class of natural therapeutic drugs [J].

Di Carlo, G ;

Mascolo, N ;

Izzo, AA ;

Capasso, F .

LIFE SCIENCES, 1999, 65 (04) :337-353

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