Human-Based Biological and Biomimetic Autologous Therapies for Musculoskeletal Tissue Regeneration

被引：42
作者：
Padilla, Sabino [1 ,2 ]
Sanchez, Mikel [3 ]
Orive, Gorka [1 ,4 ,5 ]
Anitua, Eduardo [1 ,2 ]
机构：
[1] Eduardo Anitua Fdn Biomed Res, Vitoria, Spain
[2] BTI Biotechnol Inst, Vitoria, Spain
[3] Hosp Vithas San Jose, Arthroscop Surg Unit, Vitoria, Spain
[4] Univ Basque Country, Sch Pharm, Lab Pharmaceut, NanoBioCel Grp, Vitoria, Spain
[5] Biomat & Nanomed CIBER BBN, Biomed Res Networking Ctr Bioengn, Vitoria, Spain
来源：
TRENDS IN BIOTECHNOLOGY | 2017年 / 35卷 / 03期
关键词：
PLATELET-RICH PLASMA; GROWTH-FACTORS PRGF; TENDON STEM/PROGENITOR CELLS; STEM-CELLS; CHONDROGENIC DIFFERENTIATION; CLINICAL-APPLICATION; UP-REGULATION; MUSCLE; OSTEOARTHRITIS; INJECTIONS;
D O I：
10.1016/j.tibtech.2016.09.008
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Repairing and regenerating damaged musculoskeletal tissues is one of the greatest challenges in regenerative medicine. Blood contains the essential ingredients to biologically engineer drug delivery devices that provide spatio-temporal control over the availability of a wide range of autologous agents, including small molecules, cytokines, and growth factors. This opinion article summarizes our current knowledge of blood-derived biological drug delivery therapies. The potential mechanisms that control protein release are discussed, along with the biological rationale and effects of their use in different relevant musculoskeletal tissues, including articular cartilage, bone, tendon, muscle, and nerve tissue injuries. Finally, we finally describe the current challenges facing the field and recent advances that should drive novel solutions for the musculoskeletal system.
引用
收藏
页码：192 / 202
页数：11
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