Design of Peptidic Foldamer Helices: A Stereochemical Patterning Approach

被引：101

作者：

Mandity, Istvan M. ^{[1
]}

Weber, Edit ^{[1
]}

Martinek, Tamas A. ^{[1
]}

Olajos, Gabor ^{[1
]}

Toth, Gabor K. ^{[1
]}

Vass, Elemer ^{[2
]}

Fueloep, Ferenc ^{[1
]}

机构：

[1] Univ Szeged, Inst Pharmaceut Chem & Med Chem, H-6720 Szeged, Hungary

[2] Eotvos Lorand Univ, Dept Organ Chem, H-1117 Budapest, Hungary

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 12期

关键词：

amino acids; foldamers; helical structures; NMR spectroscopy; peptides; DE-NOVO DESIGN; BETA-AMINO-ACID; ALPHA/BETA-PEPTIDES; SECONDARY STRUCTURES; CONFORMATIONS; BETA(3)-PEPTIDES; INHIBITORS; OLIGOMERS; BACKBONE; FORM;

D O I：

10.1002/anie.200805095

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Assembly language: The programmed sequences of stereochemical building blocks lead to novel biometric helices. The rational design approach offers new possibilities for creating periodic secondary strutures. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2171 / 2175

页数：5

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