Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation

被引：114
作者：
Häusler, KD [1 ]
Horwood, NJ [1 ]
Chuman, Y [1 ]
Fisher, JL [1 ]
Ellis, J [1 ]
Martin, TJ [1 ]
Rubin, JS [1 ]
Gillespie, MT [1 ]
机构：
[1] NCI, NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 11期
关键词：
osteoclast; RANKL; secreted frizzled-related protein; Wnt;
D O I：
10.1359/JBMR.040807
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We determined that sFRP-1 mRNA was differentially expressed by osteoblast/stromal cell lines and that sFRP-1 neutralizing antibodies and siRNA complementary to sFRP-1 coding sequence enhanced, while recombinant sFRP-1 inhibited, osteoclast formation. In studying the mechanism of action for sFRP-1, we found that sFRP-1 could bind recombinant RANKL. These results suggest potential cross-talk between Wnt and RANKL pathways.
引用
收藏
页码：1873 / 1881
页数：9
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