Synthesis of coumarin derivatives with cytotoxic, antibacterial and antifungal activity

被引：82

作者：

Khan, KM ^{[1
]}

Saify, ZS

Khan, MZ

Zia-Ullah

Choudhary, MI

Atta-ur-Rahman

Perveen, S

Chohan, ZH

Supuran, CT

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan

[2] PCSIR Labs Complex, Karachi 75280, Pakistan

[3] Bahauddin Zakariya Univ, Dept Chem, Multan 60800, Pakistan

[4] Univ Florence, Dipartimento Chim, Lab Chim Bioinorgan, Polo Sci, Sesto Fiorentino, Frienze, Italy

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2004年 / 19卷 / 04期

关键词：

coumarin derivatives; antibacterial; antifungal; cytotoxic agent;

D O I：

10.1080/14756360409162453

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and selective biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and some of their derivatives were carried out. Compound 13 was found to be most potent cytotoxic agent with LD50=126.69 mug/ml. In antibacterial assay the compounds showed a broad spectrum of activities. Compound 11 exhibited a very high degree of plant growth inhibition at three levels of concentration. Compound 4 showed very promising antifungal activity against Candida albicans. Compounds 12 and 13 demonstrated excellent antioxidant activity.

引用

页码：373 / 379

页数：7

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