The Complexity of TET2 Functions in Pluripotency and Development

被引：11
作者：
Garcia-Outeiral, Vera [1 ]
de la Parte, Cristina [2 ]
Fidalgo, Miguel [1 ]
Guallar, Diana [2 ]
机构：
[1] Univ Santiago de Compostela, Dept Physiol, Stem Cells & Human Dis Grp, Ctr Res Mol Med & Chron Dis, Santiago De Compostela, Spain
[2] Univ Santiago de Compostela, Dept Biochem & Mol Biol, Epitranscript & Ageing Grp, Ctr Res Mol Med & Chron Dis, Santiago De Compostela, Spain
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 8卷
关键词：
TET2; epigenetic; epitranscriptomic; pluripotency; reprogramming; development; 5hmC; METHYLCYTOSINE OXIDASES TET1; HEMATOPOIETIC STEM-CELLS; DNA DEMETHYLATION; ENHANCER ACTIVITY; SELF-RENEWAL; MOUSE EMBRYO; PROTEINS; METHYLATION; 5-HYDROXYMETHYLCYTOSINE; ROLES;
D O I：
10.3389/fcell.2020.630754
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ten-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of biological processes, including embryonic development and tissue homeostasis. TET2 catalyzes the demethylation of 5-methylcytosine on DNA, affecting transcriptional regulation. New exciting research has provided evidence for TET2 catalytic activity in post-transcriptional regulation through RNA hydroxymethylation. Here we review the current understanding of TET2 functions on both DNA and RNA, and the influence of these chemical modifications in normal development and pluripotency contexts, highlighting TET2 versatility in influencing genome regulation and cellular phenotypes.
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页数：9
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