Albumin Carriers for Cancer Theranostics: A Conventional Platform with New Promise

被引：254

作者：

Chen, Qian ^{[1
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 47期

基金：

中国国家自然科学基金;

关键词：

HUMAN-SERUM-ALBUMIN; GUIDED PHOTOTHERMAL THERAPY; DRUG BINDING-SITES; IN-VIVO; PHOTODYNAMIC THERAPY; COMBINATION THERAPY; DESOLVATION PROCESS; FERRITIN NANOCAGES; GOLD NANOPARTICLES; ANTITUMOR-ACTIVITY;

D O I：

10.1002/adma.201600038

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Theranostic nanoplatforms with integrated diagnostic and therapeutic functions, aiming at imaging-guided therapy to improve treatment planning, as well as combination therapy to enhance treatment efficacy, have received tremendous attention in recent years. Among numerous types of functional nanomaterials explored in this field, protein-based nanocarriers with inherent biocompatibility have also been selected as building blocks to construct multifunctional theranostic platforms. In particular, albumin, which has been extensively used as drug-delivery carriers for decades, has shown great new promise in the construction of novel imaging and therapeutic nanoagents, as demonstrated by a number of recent studies. IHere, the motivations of using albumins to build up nanoscale theranostics are discussed, and the latest progress/future perspectives in this direction are summarized.

引用

页码：10557 / 10566

页数：10

共 103 条

[1] Characterization of subdomain IIA binding site of human serum albumin in its native, unfolded, and refolded states using small molecular probes [J].

Abou-Zied, Osama K. ;

Al-Shihi, Othman I. K. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (32) :10793-10801

[2] Bovine serum albumin (BSA) and cleaved-BSA conjugated ultrasmall Gd2O3 nanoparticles: Synthesis, characterization, and application to MRI contrast agents [J].

Ahmad, Md. Wasi ;

Kim, Cho Rong ;

Baeck, Jong Su ;

Chang, Yongmin ;

Kim, Tae Jeong ;

Bae, Ji Eun ;

Chaed, Kwon Seok ;

Lee, Gang Ho .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2014, 450 :67-75

[3] INCREASING ACTIVITY OF SULFONAMIDES WITH DISPLACING AGENTS - REVIEW [J].

ANTON, AH .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1973, 226 (NOV26) :273-292

[4] Albumin nanoparticles improved the stability, nuclear accumulation and anticytomegaloviral activity of a phosphodiester oligonucleotide [J].

Arnedo, A ;

Irache, JM ;

Merodio, M ;

Millán, MSE .

JOURNAL OF CONTROLLED RELEASE, 2004, 94 (01) :217-227

[5] Theranostic Nanoshells: From Probe Design to Imaging and Treatment of Cancer [J].

Bardhan, Rizia ;

Lal, Surbhi ;

Joshi, Amit ;

Halas, Naomi J. .

ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :936-946

[6] The Advancement of Human Serum Albumin-Based Molecular Probes for Molecular Imaging [J].

Cao, Wei ;

Lu, Xiaoting ;

Cheng, Zhen .

CURRENT PHARMACEUTICAL DESIGN, 2015, 21 (14) :1908-1915

[7]

CARTER DC, 1994, ADV PROTEIN CHEM, V45, P153

[8] Human serum albumin unfolding pathway upon drug binding: A thermodynamic and spectroscopic description [J].

Cheema, Mohammad Arif ;

Taboada, Pablo ;

Barbosa, Silvia ;

Juarez, Josue ;

Gutierrez-Pichel, Manuel ;

Siddiq, Mohammad ;

Mosquera, Victor .

JOURNAL OF CHEMICAL THERMODYNAMICS, 2009, 41 (04) :439-447

[9] The preparation and characterization of folate-conjugated human serum albumin magnetic cisplatin nanoparticles [J].

Chen, Daozhen ;

Tang, Qiusha ;

Xue, Wenqun ;

Xiang, Jingying ;

Zhang, Li ;

Wang, Xinru .

JOURNAL OF BIOMEDICAL RESEARCH, 2010, 24 (01) :26-32

[10] A Self-Assembled Albumin-Based Nanoprobe for In Vivo Ratiometric Photoacoustic pH Imaging [J].

Chen, Qian ;

Liu, Xiaodong ;

Chen, Jiawen ;

Zeng, Jianfeng ;

Cheng, Zhenping ;

Liu, Zhuang .

ADVANCED MATERIALS, 2015, 27 (43) :6820-+

← 1 2 3 4 5 6 7 8 9 10 →