Fluorescence in situ hybridization analysis of HER-2/neu, c-myc, and p53 in endometrial cancer

被引：29

作者：

Williams, JA ^{[1
]}

Wang, ZR ^{[1
]}

Parrish, RS ^{[1
]}

Hazlett, LJ ^{[1
]}

Smith, ST ^{[1
]}

Young, SR ^{[1
]}

机构：

[1] Univ S Carolina, Dept Obstet & Gynecol, Columbia, SC 29203 USA

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 1999年 / 67卷 / 03期

关键词：

D O I：

10.1006/exmp.1999.2289

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Our objective was to evaluate the association between HER-2/neu, c-myc, p53, and clinicopathologic Variables in endometrial cancer using fluorescence in situ hybridization (FISH) cytogenetic analysis. FISH analysis for KER-2/neu, c-myc, and p53 was performed on 47 endometrial cancer specimens. Amplification of HER-2/neu was seen in 4/47 (8.5%) cases and amplification of c-myc was seen in 7 of 47 (15%) cases; neither was associated with adverse clinicopathologic variables or survival. Deletion of p53 was seen in 31/47 (66%) cases and was associated with poor histologic grade (P = 0.008). There was no impact of genetic alterations on overall survival or disease-free interval. Grade 3 tumor was associated with poor overall survival (P = 0.032). This study found that p53 deletion is a common genetic alteration in endometrial cancer and is associated with poor-grade tumors. (C) 1999 Academic Press.

引用

页码：135 / 143

页数：9

共 28 条

[1]

BERCHUCK A, 1995, CANCER, V76, P2034, DOI 10.1002/1097-0142(19951115)76:10+<2034::AID-CNCR2820761321>3.0.CO

[2]

2-U

[3] OVEREXPRESSION OF HER-2 NEU IN ENDOMETRIAL CANCER IS ASSOCIATED WITH ADVANCED STAGE DISEASE [J].

BERCHUCK, A ;

RODRIGUEZ, G ;

KINNEY, RB ;

SOPER, JT ;

DODGE, RK ;

CLARKEPEARSON, DL ;

BAST, RC .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1991, 164 (01) :15-21

[4]

BERCHUCK A, 1990, CANCER RES, V50, P4087

[5] ONCOGENE ALTERATIONS IN ENDOMETRIAL CARCINOMA [J].

BORST, MP ;

BAKER, VV ;

DIXON, D ;

HATCH, KD ;

SHINGLETON, HM ;

MILLER, DM .

GYNECOLOGIC ONCOLOGY, 1990, 38 (03) :364-366

[6] OVARIAN-CANCER - PROTOCOL FOR THE PREPARATION OF BANDED METAPHASES FROM TUMOR-TISSUE [J].

CHATTOPADHYAY, S ;

MARINDUQUE, B ;

GILBERT, F .

CANCER GENETICS AND CYTOGENETICS, 1992, 59 (02) :210-212

[7] TYROSINE KINASE RECEPTOR WITH EXTENSIVE HOMOLOGY TO EGF RECEPTOR SHARES CHROMOSOMAL LOCATION WITH NEU ONCOGENE [J].

COUSSENS, L ;

YANGFENG, TL ;

LIAO, YC ;

CHEN, E ;

GRAY, A ;

MCGRATH, J ;

SEEBURG, PH ;

LIBERMANN, TA ;

SCHLESSINGER, J ;

FRANCKE, U ;

LEVINSON, A ;

ULLRICH, A .

SCIENCE, 1985, 230 (4730) :1132-1139

[8]

Cox D. R., 1984, ANAL SURVIVAL DATA

[9]

Godwin A. K., 1997, P107

[10] Prognostic value of p53 and proliferating cell nuclear antigen expression in endometrial carcinoma [J].

Hamel, NW ;

Sebo, TJ ;

Wilson, TO ;

Keeney, GL ;

Roche, PC ;

Suman, VJ ;

Hu, TC ;

Podratz, KC .

GYNECOLOGIC ONCOLOGY, 1996, 62 (02) :192-198

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