Do functional changes occur in the bladder due to bladder outlet obstruction? - ICI-RS 2018

被引：37

作者：

Bosch, Ruud ^{[1
]}

Abrams, Paul ^{[2
]}

Averbeck, Marcio Augusto ^{[3
]}

Agro, Enrico Finazzi ^{[4
,5
]}

Gammie, Andrew ^{[6
]}

Marcelissen, Tom ^{[1
]}

Solomon, Eskinder ^{[7
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Urol, NL-3508 GA Utrecht, Netherlands

[2] Bristol Urol Inst, Dept Urol, Bristol, Avon, England

[3] Moinhos Vento Hosp, Dept Urol, Porto Alegre, RS, Brazil

[4] Univ Roma Tor Vergata, Dept Expt Med & Surg, Dept Surg, Policlin Tor Vergata, Rome, Italy

[5] Urol Unit, Rome, Italy

[6] Southmead Hosp, Bristol Urol Inst, Bristol, Avon, England

[7] Guys & St Thomas NHS Trust, Dept Urol, London, England

来源：

NEUROUROLOGY AND URODYNAMICS | 2019年 / 38卷

关键词：

bladder dysfunction; bladder outlet obstruction; detrusor contractility; overactive bladder; underactive bladder; URINARY-TRACT SYMPTOMS; SMOOTH-MUSCLE; WALL THICKNESS; YOUNG MEN; DETRUSOR UNDERACTIVITY; URODYNAMIC PATTERN; COLLAGEN CONTENT; NATURAL-HISTORY; DYSFUNCTION; EXPRESSION;

D O I：

10.1002/nau.24076

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Studies on bladder dysfunction (BD), more specifically functional-urodynamic changes in the bladder as a result of bladder outlet obstruction (BOO) have been summarized for this TT. Based on available, but limited evidence from human studies a three-stage model can be hypothesized to characterize BOO-induced bladder remodeling: hypertrophy, compensation (increased detrusor contractility during the voiding phase, often in combination with filling phase detrusor overactivity) followed by the phase of decompensation [detrusor underactivity]. The time between the start of compensation and eventual decompensation seems to be determined by age of onset, severity, and type of obstruction and clinical mitigating factors such as vascular and metabolic problems. Understanding the relative contributions of these factors may allow the development of personalized timelines and probabilities for these obstructed patients.

引用

页码：S56 / S65

页数：10

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