The Genetic Variants-717T>C (rs2794521), 1444G>A (rs1130864), and 1846 C > T (rs1205) of CRP Gene, Their Haplotypes, and Their Association with Serum CRP Levels, Acute Coronary Syndrome, and Diabetes in Patients from Western Mexico

被引:7
作者
Reynoso-Villalpando, Gabriela Lizet [1 ,2 ]
Casillas-Munoz, Fidel Antonio [1 ,2 ]
Padilla-Gutierrez, Jorge Ramon [1 ]
Sevillano-Collantes, Cristina [3 ]
Moreno-Ruiz, Inmaculada [3 ]
Del Canizo-Gomez, Francisco Javier [3 ]
Valdez-Haro, Angelica [4 ]
Martinez-Fernandez, Diana Emilia [5 ]
Valle, Yeminia [1 ]
机构
[1] Univ Guadalajara UdG, Ctr Univ Ciencias Salud CUCS, Inst Invest Ciencias Biomed, Dept Clin Med, Colonia Independencia,Sierra Mojada 950, Guadalajara, Jalisco, Mexico
[2] Ctr Univ Ciencias Salud, Doctorado Genet Humana, Guadalajara, Jalisco, Mexico
[3] Univ Complutense, Fac Med, Hosp Univ Infanta Leonor, Secc Endocrinol & Nutr, Madrid, Spain
[4] Hosp Infantil Estado Sonora, Dept Ensenanza & Calidad, Hermosillo, Sonora, Mexico
[5] Ctr Univ Ciencias Salud, Doctorado Ciencias Biomed, Guadalajara, Jalisco, Mexico
关键词
acute coronary syndrome; cardiovascular risk; CRP SNP; haplotype; high-sensitivity CRP; type 2 diabetes mellitus; REACTIVE PROTEIN GENE; HEART-DISEASE; RISK-FACTORS; POLYMORPHISM; MEDICINE; STROKE; MARKER;
D O I
10.1089/met.2020.0080
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: C-reactive protein (CRP) is involved in inflammatory pathways that are associated with the onset and progression of type 2 diabetes mellitus (T2DM) as well as an increased risk of an acute coronary syndrome (ACS). This research aimed to evaluate the potential association of the genetic variants -717T>C, 1444G>A, and 1846 C > T of CRP gene on CRP levels, ACS, and T2DM in participants from Western Mexico. Methods: Six hundred three participants were studied: (1) control group (CG); (2) ACS participants classified as unstable angina (UA), myocardial infarction without ST-segment elevation (NSTEMI), and myocardial infarction with ST-segment elevation (STEMI); (3) T2DM Participants; and (4) ACS plus T2DM participants (ACS+T2DM). Genetic variants were genotyped using allelic discrimination with TaqMan(R) probes, and high-sensitivity CRP (hs-CRP) was measured by Turbidimetry. Results: TAC haplotype frequency was significantly higher in ACS+T2DM versus CG and versus ACS participants (odds ratio [OR] = 2.774, P = 0.017 and OR = 3.479, P = 0.020, respectively). hs-CRP levels were especially higher for ACS and for ACS+T2DM participants with respect to CG and T2DM (with P < 0.0001). We observed higher hs-CRP levels in NSTEMI and STEMI versus UA in ACS scenario (P = 0.001, P = 0.027, respectively) and for ACS+T2DM scenario (P = 0.0001, P = 0.002, respectively). Conclusion: hs-CRP level fluctuations are related to the presence of T2DM and the presence and severity of ACS. Very high levels (>10 mg/L) are a risk marker of cardiovascular complications. Our results demonstrate a possible relationship between TAC haplotype and an increased risk for T2DM and ACS.
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收藏
页码:127 / 136
页数:10
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