Do cytoskeletal components control fatty acid translocation into liver mitochondria?

被引：22

作者：

Guzmán, M ^{[2
]}

Velasco, G

Geelen, MJH

机构：

[1] Univ Utrecht, Vet Biochem Lab, NL-3508 TD Utrecht, Netherlands

[2] Univ Complutense, Sch Biol, Dept Biochem & Mol Biol 1, E-28040 Madrid, Spain

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 02期

关键词：

D O I：

10.1016/S1043-2760(99)00223-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

For two decades it has been assumed that inhibition of carnitine palmitoyl-transferase I (CPT-1) by malonyl-CoA represents the main regulatory mechanism Of liver ketogenesis. However, recent evidence indicates that CPT-I activity is also controlled by interactions between mitochondria and cytoskeletal components. This newly recognized mechanism emphasizes the emerging role of the cytoskeleton in the regulation of metabolic pathways.

引用

页码：49 / 53

页数：5

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