Regulation of the Blood-Brain Barrier by Circadian Rhythms and Sleep

被引：137

作者：

Cuddapah, Vishnu Anand ^{[1
,2
,3
]}

Zhang, Shirley L. ^{[2
,3
]}

Sehgal, Amita ^{[2
,3
]}

机构：

[1] Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Ctr Sleep & Circadian Neurobiol, Chronobiol Program, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

来源：

TRENDS IN NEUROSCIENCES | 2019年 / 42卷 / 07期

关键词：

TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA; CEREBROSPINAL-FLUID; P-GLYCOPROTEIN; SPINAL-CORD; INTERSTITIAL FLUID; PROSTAGLANDIN D-2; DIURNAL-VARIATION; BETA CLEARANCE; TRANSPORT;

D O I：

10.1016/j.tins.2019.05.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The blood-brain barrier (BBB) is an evolutionarily conserved, structural, and functional separation between circulating blood and the central nervous system (CNS). By controlling permeability into and out of the nervous system, the BBB has a critical role in the precise regulation of neural processes. Here, we review recent studies demonstrating that permeability at the BBB is dynamically controlled by circadian rhythms and sleep. An endogenous circadian rhythm in the BBB controls transporter function, regulating permeability across the BBB. In addition, sleep promotes the clearance of metabolites along the BBB, as well as endocytosis across the BBB. Finally, we highlight the implications of this regulation for diseases, including epilepsy.

引用

页码：500 / 510

页数：11

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