共 2 条
Characteristics and frequency of DEL phenotype detected by indirect antiglobulin test in Dalmatia county of Croatia
被引:8
|作者:
Dajak, Slavica
[1
]
Krstic, Jelena Lukacevic
[1
]
Koermoeczi, Guenther
[2
]
Dogic, Vesna
[3
]
Burilovic, Vedrana
[1
]
机构:
[1] Split Univ, Ctr Hosp, Dept Transfus Med, Split 21000, Croatia
[2] Med Univ Vienna, Dept Blood Grp Serol & Transfus Med, Vienna, Austria
[3] Croatian Inst Transfus Med, Zagreb, Croatia
关键词:
Weak D variants;
Indirect antiglobulin test;
Genotyping RHD;
ANTI-D IMMUNIZATION;
D-BLOOD-DONORS;
RHD GENE;
D-EL;
INDIVIDUALS;
ALLELES;
D O I:
10.1016/j.transci.2014.01.019
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
D variants, collectively called DEL, express trace amounts of D antigen which is considered to be serologically detectable only by adsorption-elution techniques. We detected six cases of DEL phenotype by indirect antiglobulin test, in Dalmatia County of Croatia by routine serological testing of D antigen of new blood donors. RH genotyping found that all six donors carry allele RHD(M295I), RH genotype CcDdee. D antigen densities of D variants were very low, between 26 and 44 D antigens per red blood cell. The frequency of D variants detected by IAT allele RHD(M295I) was 1:272 in D negative donors. Obviously, DEL phenotype is more common in some parts of European population than initially thought. In conclusion, our routine serological testing of D antigen can detect extremely weak D antigen, even RBCs with DEL phenotype and antigen density as low as 26 D antigens per RBC. (C) 2014 Elsevier Ltd. All rights reserved.
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页码:210 / 213
页数:4
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