Urinary Metabolites of Di(2-ethylhexyl) Phthalate Are Associated With Decreased Steroid Hormone Levels in Adult Men

被引:172
作者
Meeker, John D. [1 ]
Calafat, Antonia M. [2 ]
Hauser, Russ [3 ,4 ,5 ]
机构
[1] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
[2] Ctr Dis Control & Prevent, Atlanta, GA USA
[3] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
[4] Massachusetts Gen Hosp, Vincent Mem Obstet & Gynecol Serv, Androl Lab, Boston, MA 02114 USA
[5] Massachusetts Gen Hosp, Vitro Fertilizat Unit, Boston, MA 02114 USA
来源
JOURNAL OF ANDROLOGY | 2009年 / 30卷 / 03期
基金
美国国家卫生研究院;
关键词
Androgen; biomarker; endocrine; environment; human; estrogen; male reproduction; testosterone; MALE REPRODUCTIVE-SYSTEM; RAT GRANULOSA-CELLS; MONO-(2-ETHYLHEXYL) PHTHALATE; QUANTITATIVE DETECTION; OXIDATIVE METABOLITES; TEMPORAL VARIABILITY; ESTRADIOL PRODUCTION; MALE-INFERTILITY; DNA-DAMAGE; IN-UTERO;
D O I
10.2164/jandrol.108.006403
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
Experimental animal studies have demonstrated that exposure to some phthalates may be associated with altered endocrine function and adverse effects on male reproductive development and function, but human studies are limited. In the present study, urine and serum samples were collected from 425 men recruited through a US infertility clinic. Urinary concentrations of mono(2-ethylhexyl) phthalate (MEHP), the hydrolytic metabolite of di(2-ethylhexyl) phthalate (DEHP), and other phthalate monoester metabolites were measured, along with serum levels of testosterone, estradiol, sex hormone-binding globulin (SHBG), follicle-stimulating hormone, luteinizing hormone, inhibin B, and prolactin. Two oxidized urinary metabolites of DEHP were also measured in urine from 221 of the men. In multiple regression models adjusted for potential confounders, MEHP was inversely associated with testosterone, estradiol, and free androgen index (FAI). An interquartile range increase in MEHP was associated with 3.7% (95% confidence interval [CI], -6.8% to -0.5%) and 6.8% (95% Cl, -11.2% to -2.4%) declines in testosterone and estradiol, respectively, relative to the population median hormone levels. There was limited evidence for effect modification of the inverse association between MEHP and FAI by the proportion of DEHP metabolites in the urine measured as MEHP (MEHP%), which is considered a phenotypic marker of less efficient metabolism of DEHP to its oxidized metabolites. Finally, the ratio of testosterone to estradiol was positively associated with MEHP (P = .07) and MEHP% (P = .007), suggesting potential relationships with aromatase suppression. In conclusion, these results suggest that urinary metabolites of DEHP are inversely associated with circulating steroid hormone levels in adult men. However, additional research is needed to confirm these findings.
引用
收藏
页码:287 / 297
页数:11
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