Radical Carbonylation Mediated by Continuous-Flow Visible-Light Photocatalysis: Access to 2,3-Dihydrobenzofurans

被引：47
作者：
Micic, Nenad [1 ]
Polyzos, Anastasios [2 ]
机构：
[1] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia
[2] CSIRO Mfg, Res Way, Clayton, Vic 3168, Australia
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 15期
关键词：
TYPE-2; DIABETES-MELLITUS; PHOTOREDOX CATALYSIS; CARBON-MONOXIDE; CYCLIZATION; PHOTOCHEMISTRY; COMPLEXES; HYDRIDE; DYES;
D O I：
10.1021/acs.orglett.8b01971
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The annulative carbonylation of alkenyl-tethered arenediazonium salts using visible-light photo catalysis in continuous flow is described. The method furnishes a diverse series of novel acetate-functionalized 2,3-dihydrobenzofurans at room temperature and moderate CO pressure (25 atm), delivering these products in a short time with straightforward scale-up. This continuous flow and free radical approach overcomes the limitation of traditional Pd-catalyzed annulative carbonylation, giving valuable 2,3-dihydrobenzofurans in a predictable and regioselective manner.
引用
收藏
页码：4663 / 4666
页数：4
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