Simultaneous introduction of HIV type 1 subtype A and B viruses into injecting drug users in southern Ukraine at the beginning of the epidemic in the former Soviet Union

被引：53

作者：

Nabatov, AA

Kravchenko, ON

Lyulchuk, MG

Shcherbinskaya, AM

Lukashov, VV

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Human Retrovirol, NL-1105 AZ Amsterdam, Netherlands

[2] Ukraine Acad Med Sci, Inst Epidemiol & Infect Dis, UA-03038 Kiev, Ukraine

[3] Russian Acad Med Sci, DI Ivanovsky Inst Virol, Moscow 123098, Russia

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2002年 / 18卷 / 12期

关键词：

D O I：

10.1089/08892220260190380

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The vast majority of HIV-1 strains from the epidemic in the former Soviet Union (FSU) belong to subtype A (IDU-A) and CRF03_AB (IDU-A/B), for which IDU-A is one of parental strains; no epidemic by another parental virus, belonging to subtype B (IDU-B), has yet been identified. To characterize viruses present during the early stage of the epidemic in southern Ukraine, where the first outbreaks in the FSU were registered, we obtained partial env and pol sequences from IDUs from Odessa and Nikolaev and compared them with viruses from other outbreaks. All viruses from Odessa belonged to the IDU-A type, which is in accord with previous studies. At the same time, we found that the outbreak in Nikolaev was caused by IDU-B viruses, indicating that this outbreak is the result of an independent virus introduction. Phylogenetic analysis of viruses from the FSU supported the epidemiological data suggesting that the HIV-1 epidemic in the FSU started in southern Ukraine.

引用

收藏

页码：891 / 895

页数：5

相关论文

共 11 条

[1] The HIV/AIDS epidemic in Ukraine: its potential social and economic impact [J].

Barnett, T ;

Whiteside, A ;

Khodakevich, L ;

Kruglov, Y ;

Steshenko, V .

SOCIAL SCIENCE & MEDICINE, 2000, 51 (09) :1387-1403

[2] An HIV type 1 epidemic among injecting drug users in the former Soviet Union caused by a homogeneous subtype A strain [J].

Bobkov, A ;

CheingsongPopov, R ;

Selimova, L ;

Ladnaya, N ;

Kazennova, E ;

Kravchenko, A ;

Fedotov, E ;

Saukhat, S ;

Zverev, S ;

Pokrovsky, V ;

Weber, J .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1997, 13 (14) :1195-1201

[3] A sudden epidemic of HIV type 1 among injecting drug users in the former Soviet Union:: Identification of subtype A, subtype B, and novel gagA/envB recombinants [J].

Bobkov, A ;

Kazennova, E ;

Selimova, L ;

Bobkova, M ;

Khanina, T ;

Ladnaya, N ;

Kravchenko, A ;

Pokrovsky, V ;

Cheingsong-Popov, R ;

Weber, J .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (08) :669-676

[4] The HIV epidemic associated with injecting drug use in Europe: Geographic and time trends [J].

Hamers, FF ;

Batter, V ;

Downs, AM ;

Alix, J ;

Cazein, F ;

Brunet, JB .

AIDS, 1997, 11 (11) :1365-1374

[5] An AB recombinant and its parental HIV type 1 strains in the area of the former Soviet Union: low requirements for sequence identity in recombination [J].

Liitsola, K ;

Holm, K ;

Bobkov, A ;

Pokrovsky, V ;

Smolskaya, T ;

Leinikki, P ;

Osmanov, S ;

Salminen, M .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2000, 16 (11) :1047-1053

[6] Circulation of subtype A and gagA/envB recombinant HIV type 1 strains among injecting drug users in St. Petersburg, Russia, correlates with geographical origin of infections [J].

Lukashov, VV ;

Huismans, R ;

Rakhmanova, AG ;

Lisitsina, ZN ;

Akhtyrskaya, NA ;

Vlasov, NN ;

Melnick, OB ;

Goudsmit, J .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1999, 15 (17) :1577-1583

[7] Evidence for HIV type 1 strains of US intravenous drug users as founders of AIDS epidemic among intravenous drug users in Northern Europe [J].

Lukashov, VV ;

Kuiken, CL ;

Vlahov, D ;

Coutinho, RA ;

Goudsmit, J .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1996, 12 (12) :1179-1183

[8] Sequence note - Extreme founder effect in an HIV type 1 subtype a epidemic among drug users in Svetlogorsk, Belarus [J].

Lukashov, VV ;

Karamov, EV ;

Eremin, VF ;

Titov, LP ;

Goudsmit, J .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (14) :1299-1303

[9] INTRAHOST HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 EVOLUTION IS RELATED TO LENGTH OF THE IMMUNOCOMPETENT PERIOD [J].

LUKASHOV, VV ;

KUIKEN, CL ;

GOUDSMIT, J .

JOURNAL OF VIROLOGY, 1995, 69 (11) :6911-6916

[10] Molecular epidemiology of an HIV-1 subtype A subcluster among injection drug users in the southern ukraine [J].

Novitsky, VA ;

Montano, RA ;

Essex, M .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (12) :1079-1085