U-insertion/deletion RNA editing multiprotein complexes and mitochondrial ribosomes in Leishmania tarentolae are located in antipodal nodes adjacent to the kinetoplast DNA

被引：7
作者：
Wong, Richard G. [1 ,5 ]
Kazane, Katelynn [2 ,5 ]
Maslov, Dmitri A. [3 ]
Rogers, Kestrel [4 ]
Aphasizhev, Ruslan [6 ]
Simpson, Larry [5 ]
机构：
[1] Univ So Calif, Davis Sch Gerontol, Dept Gerontol, Los Angeles, CA 90089 USA
[2] Multispan Inc, Hayward, CA 94544 USA
[3] Univ Calif Riverside, Dept Biol, Riverside, CA 92521 USA
[4] Univ Calif Riverside, Inst Integrat Genome Biol, Dept Bot & Plant Sci, Riverside, CA 92521 USA
[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
[6] Boston Univ, Sch Dent Med, Dept Mol & Cell Biol, Boston, MA 02118 USA
来源：
MITOCHONDRION | 2015年 / 25卷
基金：
美国国家卫生研究院;
关键词：
Leishmania; RNA; Editing; Antipodal node; Trypanosome; Kinetoplast; SEQUENCE-BINDING-PROTEIN; TRYPANOSOMA-BRUCEI; REPLICATION PROTEINS; EXPRESSION SYSTEM; POLYMERASE-BETA; HELICASE; IDENTIFICATION; LOCALIZATION; ASSOCIATION; FLAGELLUM;
D O I：
10.1016/j.mito.2015.10.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We studied the intramitochondrial localization of several multiprotein complexes involved in U-insertion/deletion RNA editing in trypanosome mitochondria. The editing complexes are located in one or two antipodal nodes adjacent to the kinetoplast DNA (kDNA) disk, which are distinct from but associated with the minicircle catenation nodes. In some cases the proteins are in a bilateral sheet configuration. We also found that mitoribosomes have a nodal configuration. This type of organization is consistent with evidence for protein and RNA interactions of multiple editing complexes to form an similar to 40S editosome and also an interaction of editosomes with mitochondrial ribosomes. (C) 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
引用
收藏
页码：76 / 86
页数：11
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