Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes

被引：8

作者：

Wawina-Bokalanga, Tony ^{[1
]}

Vanmechelen, Bert ^{[1
]}

Lhermitte, Valentine ^{[1
]}

Marti-Carreras, Joan ^{[1
]}

Vergote, Valentijn ^{[1
]}

Koundouno, Fara Raymond ^{[2
]}

Akoi-Bore, Joseph ^{[3
]}

Thom, Ruth ^{[4
]}

Tipton, Tom ^{[4
]}

Steeds, Kimberley ^{[4
]}

Moussa, Keita Balla ^{[5
]}

Amento, Ablam ^{[5
]}

Laenen, Lies ^{[1
]}

Duraffour, Sophie ^{[6
,7
]}

Gabriel, Martin ^{[6
,7
]}

Ruibal, Paula ^{[7
]}

Hall, Yper ^{[4
]}

Kader-Kond, Mandy ^{[5
]}

Gunther, Stephan ^{[7
]}

Baele, Guy ^{[1
]}

Munoz-Fontela, Cesar ^{[7
]}

Van Weyenbergh, Johan ^{[1
]}

Carroll, Miles W. ^{[4
]}

Maes, Piet ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Leuven, Belgium

[2] Univ Julius Nyerere Kankan, Conakry, Guinea

[3] Inst Natl SantS Publ, Conakry, Guinea

[4] Publ Hlth England, Salisbury, Wilts, England

[5] Ctr Excellence Format & Rech Malad Prioritaires G, Conakry, Guinea

[6] German Ctr Infect Res, Hamburg, Germany

[7] Bernhard Nocht Inst Trop Med, Hamburg, Germany

来源：

EMERGING INFECTIOUS DISEASES | 2021年 / 27卷 / 01期

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

HEMORRHAGIC-FEVER; STOPPING RULES; NK CELLS; KIR; SELECTION; HLA; POLYMORPHISMS; PATHOGENESIS;

D O I：

10.3201/eid2701.202177

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). We genotyped KIRs and HLA class I alleles using DNA from uninfected controls, EVD survivors, and persons who died of EVD. The activating 2DS4-003 and inhibitory 2DL5 genes were significantly more common among persons who died of EVD; 2DL2 was more common among survivors. We used logistic regression analysis and Bayesian modeling to identify 2DL2, 2DL5, 2DS4-003, HLA-B-Bw4-Thr, and HLA-B-Bw4-Ile as probably having a significant relationship with disease outcome. Our findings highlight the importance of innate immune response against Ebola virus and show the association between KIRs and the clinical outcome of EVD.

引用

页码：76 / 84

页数：9

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