Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes

被引：8

作者：

Wawina-Bokalanga, Tony ^{[1
]}

Vanmechelen, Bert ^{[1
]}

Lhermitte, Valentine ^{[1
]}

Marti-Carreras, Joan ^{[1
]}

Vergote, Valentijn ^{[1
]}

Koundouno, Fara Raymond ^{[2
]}

Akoi-Bore, Joseph ^{[3
]}

Thom, Ruth ^{[4
]}

Tipton, Tom ^{[4
]}

Steeds, Kimberley ^{[4
]}

Moussa, Keita Balla ^{[5
]}

Amento, Ablam ^{[5
]}

Laenen, Lies ^{[1
]}

Duraffour, Sophie ^{[6
,7
]}

Gabriel, Martin ^{[6
,7
]}

Ruibal, Paula ^{[7
]}

Hall, Yper ^{[4
]}

Kader-Kond, Mandy ^{[5
]}

Gunther, Stephan ^{[7
]}

Baele, Guy ^{[1
]}

Munoz-Fontela, Cesar ^{[7
]}

Van Weyenbergh, Johan ^{[1
]}

Carroll, Miles W. ^{[4
]}

Maes, Piet ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Leuven, Belgium

[2] Univ Julius Nyerere Kankan, Conakry, Guinea

[3] Inst Natl SantS Publ, Conakry, Guinea

[4] Publ Hlth England, Salisbury, Wilts, England

[5] Ctr Excellence Format & Rech Malad Prioritaires G, Conakry, Guinea

[6] German Ctr Infect Res, Hamburg, Germany

[7] Bernhard Nocht Inst Trop Med, Hamburg, Germany

来源：

EMERGING INFECTIOUS DISEASES | 2021年 / 27卷 / 01期

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

HEMORRHAGIC-FEVER; STOPPING RULES; NK CELLS; KIR; SELECTION; HLA; POLYMORPHISMS; PATHOGENESIS;

D O I：

10.3201/eid2701.202177

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). We genotyped KIRs and HLA class I alleles using DNA from uninfected controls, EVD survivors, and persons who died of EVD. The activating 2DS4-003 and inhibitory 2DL5 genes were significantly more common among persons who died of EVD; 2DL2 was more common among survivors. We used logistic regression analysis and Bayesian modeling to identify 2DL2, 2DL5, 2DS4-003, HLA-B-Bw4-Thr, and HLA-B-Bw4-Ile as probably having a significant relationship with disease outcome. Our findings highlight the importance of innate immune response against Ebola virus and show the association between KIRs and the clinical outcome of EVD.

引用

页码：76 / 84

页数：9

共 50 条

[21] Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis
Hanson, Aimee L.
Vukcevic, Damjan
Leslie, Stephen
Harris, Jessica
Cao, Kim-Anh Le
Kenna, Tony J.
Brown, Matthew A.
PLOS GENETICS, 2020, 16 (08):
[22] Impact of Human Leukocyte Antigen Allele-Killer Cell Immunoglobulin-like Receptor Partners on Sexually Transmitted Human Immunodeficiency Virus Type 1 Infection
Serrano-Risquez, Carmen
Omar, Mohamed
Rallon, Norma
Benito, Jose Miguel
Gomez-Vidal, Amparo
Marquez, Francisco J.
Aljan, Martina
Rivero-Juarez, Antonio
Perez-Valero, Ignacio
Rivero, Antonio
Sinangil, Faruk
Saulle, Irma
Biasin, Mara
Clerici, Mario
Forthal, Donald
Saez, Maria Eugenia
Caruz, Antonio
JOURNAL OF INFECTIOUS DISEASES, 2024, 230 (05) : e1077 - e1081
[23] Distribution of human killer cell immunoglobulin-like receptors and ligands among blood donors of Catalonia
Closa, Laia
Vidal, Francisco
Herrero, Maria J.
Caro, Jose L.
HLA, 2020, 95 (03) : 179 - 188
[24] Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B
Vivian, Julian P.
Duncan, Renee C.
Berry, Richard
O'Connor, Geraldine M.
Reid, Hugh H.
Beddoe, Travis
Gras, Stephanie
Saunders, Philippa M.
Olshina, Maya A.
Widjaja, Jacqueline M. L.
Harpur, Christopher M.
Lin, Jie
Maloveste, Sebastien M.
Price, David A.
Lafont, Bernard A. P.
McVicar, Daniel W.
Clements, Craig S.
Brooks, Andrew G.
Rossjohn, Jamie
NATURE, 2011, 479 (7373) : 401 - U155
[25] Recurrent miscarriage is associated with a decline of decidual natural killer cells expressing killer cell immunoglobulin-like receptors specific for human leukocyte antigen C
Wang, Shan
Li, Yan-Ping
Ding, Bo
Zhao, Yue-Ran
Chen, Zi-Jiang
Xu, Cheng-Yan
Fu, Yi-Bing
Wang, Xie-Tong
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2014, 40 (05) : 1288 - 1295
[26] Genotypic diversity of the Killer Cell Immunoglobulin-like Receptors ( KIR) and their HLA class I Ligands in a Saudi population
Al Omar, Suliman Y.
Alkuriji, Afrah
Alwasel, Saleh
Dar, Javid Ahmed
Alhammad, Alwaleed
Christmas, Stephen
Mansour, Lamjed
GENETICS AND MOLECULAR BIOLOGY, 2016, 39 (01) : 14 - 23
[27] Correlation between human leukocyte antigen ligands and killer cell immunoglobulin-like receptors in aplastic anemia patients from Shaanxi Han
Tianju Wang
Jun Qi
Manni Wang
Hua Xu
Junhua Wu
Lixia Shang
Le Chen
Yuhui Li
Immunogenetics, 2023, 75 : 445 - 454
[28] Correlation between human leukocyte antigen ligands and killer cell immunoglobulin-like receptors in aplastic anemia patients from Shaanxi Han
Wang, Tianju
Qi, Jun
Wang, Manni
Xu, Hua
Wu, Junhua
Shang, Lixia
Chen, Le
Li, Yuhui
IMMUNOGENETICS, 2023, 75 (05) : 445 - 454
[29] A structural perspective on MHC class I recognition by killer cell immunoglobulin-like receptors
Boyington, JC
Sun, PD
MOLECULAR IMMUNOLOGY, 2002, 38 (14) : 1007 - 1021
[30] Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes
Jobim, Mariana
Chagastelles, Pedro
Salim, Patricia H.
Portela, Pamela
Wilson, Timothy J.
Curti, Alessandra G.
Jobim, Maria Regina
Joao, Daniele A.
Nardi, Nance Beyer
Tschiedel, Balduino
Jobim, Luiz Fernando
Roesler, Rafael
Schwartsmann, Gilberto
HUMAN IMMUNOLOGY, 2010, 71 (08) : 799 - 803

← 1 2 3 4 5 →