2D Nanoclay for Biomedical Applications: Regenerative Medicine, Therapeutic Delivery, and Additive Manufacturing

被引：296
作者：
Gaharwar, Akhilesh K. [1 ,2 ,3 ]
Cross, Lauren M. [1 ]
Peak, Charles W. [1 ]
Gold, Karli [1 ]
Carrow, James K. [1 ]
Brokesh, Anna [1 ]
Singh, Kanwar Abhay [1 ]
机构：
[1] Texas A&M Univ, Biomed Engn, Dwight Look Coll Engn, College Stn, TX 77843 USA
[2] Texas A&M Univ, Mat Sci & Engn, Dwight Look Coll Engn, College Stn, TX 77843 USA
[3] Texas A&M Univ, Ctr Remote Hlth Technol & Syst, College Stn, TX 77843 USA
来源：
ADVANCED MATERIALS | 2019年 / 31卷 / 23期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
2D nanomaterials; 3D printing; bioprinting; drug delivery; nanoclay; nanosilicates; tissue engineering; ANGLE NEUTRON-SCATTERING; DYNAMIC LIGHT-SCATTERING; DIVALENT METAL-ION; CROSS-LINKED PEO; OSTEOGENIC DIFFERENTIATION; NANOCOMPOSITE HYDROGELS; POLY(ETHYLENE GLYCOL); NANOENGINEERED HYDROGELS; SILICATE NANOPARTICLES; MECHANICAL-PROPERTIES;
D O I：
10.1002/adma.201900332
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Clay nanomaterials are an emerging class of 2D biomaterials of interest due to their atomically thin layered structure, charged characteristics, and well-defined composition. Synthetic nanoclays are plate-like polyions composed of simple or complex salts of silicic acids with a heterogeneous charge distribution and patchy interactions. Due to their biocompatible characteristics, unique shape, high surface-to-volume ratio, and charge, nanoclays are investigated for various biomedical applications. Here, a critical overview of the physical, chemical, and physiological interactions of nanoclay with biological moieties, including cells, proteins, and polymers, is provided. The state-of-the-art biomedical applications of 2D nanoclay in regenerative medicine, therapeutic delivery, and additive manufacturing are reviewed. In addition, recent developments that are shaping this emerging field are discussed and promising new research directions for 2D nanoclay-based biomaterials are identified.
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页数：28
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