2D Nanoclay for Biomedical Applications: Regenerative Medicine, Therapeutic Delivery, and Additive Manufacturing

被引：316

作者：

Gaharwar, Akhilesh K. ^{[1
,2
,3
]}

Cross, Lauren M. ^{[1
]}

Peak, Charles W. ^{[1
]}

Gold, Karli ^{[1
]}

Carrow, James K. ^{[1
]}

Brokesh, Anna ^{[1
]}

Singh, Kanwar Abhay ^{[1
]}

机构：

[1] Texas A&M Univ, Biomed Engn, Dwight Look Coll Engn, College Stn, TX 77843 USA

[2] Texas A&M Univ, Mat Sci & Engn, Dwight Look Coll Engn, College Stn, TX 77843 USA

[3] Texas A&M Univ, Ctr Remote Hlth Technol & Syst, College Stn, TX 77843 USA

来源：

ADVANCED MATERIALS | 2019年 / 31卷 / 23期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

2D nanomaterials; 3D printing; bioprinting; drug delivery; nanoclay; nanosilicates; tissue engineering; ANGLE NEUTRON-SCATTERING; DYNAMIC LIGHT-SCATTERING; DIVALENT METAL-ION; CROSS-LINKED PEO; OSTEOGENIC DIFFERENTIATION; NANOCOMPOSITE HYDROGELS; POLY(ETHYLENE GLYCOL); NANOENGINEERED HYDROGELS; SILICATE NANOPARTICLES; MECHANICAL-PROPERTIES;

D O I：

10.1002/adma.201900332

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Clay nanomaterials are an emerging class of 2D biomaterials of interest due to their atomically thin layered structure, charged characteristics, and well-defined composition. Synthetic nanoclays are plate-like polyions composed of simple or complex salts of silicic acids with a heterogeneous charge distribution and patchy interactions. Due to their biocompatible characteristics, unique shape, high surface-to-volume ratio, and charge, nanoclays are investigated for various biomedical applications. Here, a critical overview of the physical, chemical, and physiological interactions of nanoclay with biological moieties, including cells, proteins, and polymers, is provided. The state-of-the-art biomedical applications of 2D nanoclay in regenerative medicine, therapeutic delivery, and additive manufacturing are reviewed. In addition, recent developments that are shaping this emerging field are discussed and promising new research directions for 2D nanoclay-based biomaterials are identified.

引用

页数：28

共 192 条

[1] Use of clays as drug delivery systems: Possibilities and limitations [J].

Aguzzi, C. ;

Cerezo, P. ;

Viseras, C. ;

Caramella, C. .

APPLIED CLAY SCIENCE, 2007, 36 (1-3) :22-36

[2] Development of a clay based bioink for 3D cell printing for skeletal application [J].

Ahlfeld, T. ;

Cidonio, G. ;

Kilian, D. ;

Duin, S. ;

Akkineni, A. R. ;

Dawson, J. I. ;

Yang, S. ;

Lode, A. ;

Oreffo, R. O. C. ;

Gelinsky, M. .

BIOFABRICATION, 2017, 9 (03)

[3]

Amini Ami R., 2012, Critical Reviews in Biomedical Engineering, V40, P363

[4] An injectable shear-thinning biomaterial for endovascular embolization [J].

Avery, Reginald K. ;

Albadawi, Hassan ;

Akbari, Mohsen ;

Zhang, Yu Shrike ;

Duggan, Michael J. ;

Sahani, Dushyant V. ;

Olsen, Bradley D. ;

Khademhosseini, Ali ;

Oklu, Rahmi .

SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (365)

[5] COLLOIDAL PROPERTIES OF SYNTHETIC HECTORITE CLAY DISPERSIONS .2. LIGHT AND SMALL-ANGLE NEUTRON-SCATTERING [J].

AVERY, RG ;

RAMSAY, JDF .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1986, 109 (02) :448-454

[6]

B. Y. K. Additives, 2019, TECHNICAL INFORM B R

[7] Harnessing the Noncovalent Interactions of DNA Backbone with 2D Silicate Nanodisks To Fabricate Injectable Therapeutic Hydrogels [J].

Basu, Sayantani ;

Pacelli, Settimio ;

Feng, Yi ;

Lu, Qinghua ;

Wang, Jinxi ;

Paul, Arghya .

ACS NANO, 2018, 12 (10) :9866-9880

[8]

Beldon P., 2010, Surgery, V28, P409, DOI [DOI 10.1016/J.MPSUR.2010.05.007, 10.1016/J.MPSUR.2010.05.007]

[9] INDEPENDENT REGULATION OF COLLAGEN TYPES BY CHONDROCYTES DURING THE LOSS OF DIFFERENTIATED FUNCTION IN CULTURE [J].

BENYA, PD ;

PADILLA, SR ;

NIMNI, ME .

CELL, 1978, 15 (04) :1313-1321

[10] Structure and Thermorheology of Concentrated Pluronic Copolymer Micelles in the Presence of Laponite Particles [J].

Boucenna, Imane ;

Royon, Laurent ;

Colinart, Pierre ;

Guedeau-Boudeville, Marie-Alice ;

Mourchid, Ahmed .

LANGMUIR, 2010, 26 (18) :14430-14436

← 1 2 3 4 5 6 7 8 9 10 →