Synthesis of monodisperse magnetite nanoparticles via chitosan-poly (acrylic acid) template and their application in MRI

被引：52
|
作者：
Feng, B. [2 ]
Hong, R. Y. [1 ,2 ,3 ]
Wu, Y. J. [2 ]
Liu, G. H. [4 ]
Zhong, L. H. [3 ]
Zheng, Y. [5 ]
Ding, J. M. [6 ]
Wei, D. G. [7 ]
机构：
[1] Soochow Univ, SIP, Dept Chem Engn, Suzhou 215123, Peoples R China
[2] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China
[3] Chinese Acad Sci, Inst Proce Engn, State Key Lab Multiphase React, Beijing 100080, Peoples R China
[4] City Hosp Suzhou, MRI Div, E Div, Suzhou 215001, Peoples R China
[5] Univ New Brunswick, Dept Chem Engn, Fredericton, NB E3B 5A3, Canada
[6] HYDA, IBM, Rochester, MN 55901 USA
[7] Harvard Univ, Ctr Nanoscale Syst, Sch Engn & Appl Sci, Cambridge, MA 02139 USA
来源：
JOURNAL OF ALLOYS AND COMPOUNDS | 2009年 / 473卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
Nanostructured materials; Chemical synthesis; Magnetization; Transmission electron microscopy (TEM); IRON-OXIDE NANOPARTICLES; GAMMA-FE2O3; NANOPARTICLES; IN-VIVO; PARTICLES; CANCER; NANOCRYSTALS; SURFACE; NANOSPHERES;
D O I：
10.1016/j.jallcom.2008.05.094
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Ultrasmall magnetite nanoparticles were prepared by using chitosan-polyacrylic acid (CS-PAA) nanospheres as template. The CS-PAA hollow nanospheres could be prepared by polymerization of acrylic acid monomers in the presence of chitosan. The Fe3O4 loading was done by dissolving FeCl3 center dot 6H(2)O and FeSO4 center dot 7H(2)O into CS-PAA nanospheres solution followed by adding NH4OH. In finally, CS-PAA template could be removed by adjusting with HCl to pH < 1. The obtained particles were characterized by dynamic light scattering (DLS) in aqueous solution and observed by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and X-ray. The results revealed that the Fe3O4 nanoparticles were 3-5 nm in size with excellent dispersibility. From the magnetometer measurements data, the particles exhibited superparamagnetic property with saturation magnetizations of 40.7 emu/g. The MRI experiment on living rabbit showed that nanoparticles prepared by the current synthetic approach had a significant magnetic resonance signal enhancement in T2-weighted image of lymph nodes. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：356 / 362
页数：7
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