One-Pot Synthesis of 1,4-Disubstituted Pyrazoles from Arylglycines via Copper-Catalyzed Sydnone-Alkyne Cycloaddition Reaction

被引：73
|
作者：
Specklin, Simon [1 ]
Decuypere, Elodie [1 ]
Plougastel, Lucie [1 ]
Aliani, Soifia [1 ]
Taran, Frederic [1 ]
机构：
[1] CEA, Serv Chim Bioorgan & Marquage, IBiTecS, F-91191 Gif Sur Yvette, France
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 16期
关键词：
REGIOSELECTIVE SYNTHESIS; N-ARYLGLYCINES; NANO2/AC2O;
D O I：
10.1021/jo501420r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A robust method for constructing 1,4-pyrazoles from arylglycines was developed using the copper-catalyzed sydnone-alkyne cycloaddition reaction. The procedure offers a straightforward and general route to the pyrazole heterocycle through a three-step one-pot procedure.
引用
收藏
页码：7772 / 7777
页数：6
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