3-(3-Ethylphenyl)-2-substituted hydrazino-3H-quinazolin-4-one Derivatives: New Class of Analgesic and Anti-Inflammatory Agents

被引：51

作者：

Alagarsamy, V. ^{[1
]}

Solomon, V. Raja ^{[2
]}

Sheorey, R. V. ^{[3
]}

Jayakumar, R. ^{[1
]}

机构：

[1] MNR Coll Pharm, Med Chem Res Lab, Sangareddy 502294, Andhra Pradesh, India

[2] Cent Drug Res Inst, Med Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[3] Raipur Inst Technol, Inst Pharm, Dept Pharmacol, Raipur 492101, Madhya Pradesh, India

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2009年 / 73卷 / 04期

关键词：

analgesic; anti-inflammatory activity; quinazoline; structure-activity relationship; PHARMACOLOGICAL EVALUATION; ANTIBACTERIAL ACTIVITIES; 2,3-DISUBSTITUTED QUINAZOLIN-4(3H)-ONES; AMINO-3H-QUINAZOLIN-4-ONES; QUINAZOLIN-4-(3H)-ONES; QUINAZOLINES;

D O I：

10.1111/j.1747-0285.2009.00794.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new series of 3-(3-ethylphenyl)-2-substituted hydrazino-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(3-ethylphenyl)-3H-quinazolin-4-one with a variety of aldehydes and ketones. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic index behavior. The compound 2-(N'-3-pentylidene-hydrazino)-3-(3-ethylphenyl)-3H-quinazolin-4-one (AS2) emerged as the most active compound in exhibiting analgesic activity and the compound 2-(N'-2-pentylidene-hydrazino)-3-(3-ethylphenyl)-3H-quinazolin-4-one (AS3) emerged as the most active compound in exhibiting anti-inflammatory activity; and these compounds are moderately potent when compared with the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential when compared with aspirin.

引用

页码：471 / 479

页数：9

共 20 条

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