A liquid biopsy signature of circulating exosome-derived mRNAs, miRNAs and lncRNAs predict therapeutic efficacy to neoadjuvant chemotherapy in patients with advanced gastric cancer

被引:34
作者
Guo, Ting [1 ]
Tang, Xiao-Huan [1 ,2 ]
Gao, Xiang-Yu [1 ,2 ]
Zhou, Yuan [3 ]
Jin, Bo [4 ]
Deng, Zi-Qian [1 ]
Hu, Ying [5 ]
Xing, Xiao-Fang [1 ]
Li, Zi-Yu [1 ,2 ]
Ji, Jia-Fu [1 ,2 ]
机构
[1] Peking Univ, Minist Educ Beijing, Div Gastrointestinal Canc Translat Res Lab, Key Lab Carcinogenesis & Translat Res,Canc Hosp &, Beijing 100142, Peoples R China
[2] Peking Univ, Dept Gastrointestinal Surg, Canc Hosp & Inst, Beijing 100142, Peoples R China
[3] Peking Univ, Sch Basic Med Sci, Dept Biomed Informat, Beijing 100191, Peoples R China
[4] Peking Univ First Hosp, Dept Clin Lab, Beijing 100034, Peoples R China
[5] Peking Univ, Biol Sample Bank, Canc Hosp & Inst, Beijing 100142, Peoples R China
基金
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词
Exosome; Multi-omics characteristics of RNAs; Advanced gastric cancer; Neoadjuvant chemotherapy; Biomarker panel for efficacy prediction;
D O I
10.1186/s12943-022-01684-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
At present, there is no validated marker to identify the subpopulation of patients with advanced gastric cancer (AGC) who might benefit from neoadjuvant chemotherapy (NACT). In view of this clinical challenge, the identification of non-invasive biomarkers for efficacy prediction of NACT in patients with AGC is imperative. Herein, we aimed to develop a non-invasive, liquid-biopsy-based assay by using an exosome-derived RNAs model based on multi-omics characteristics of RNAs. We firstly used a multi-omics strategy to characterize the mRNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) profiles of circulating exosome enriched fractions in responders to NACT paired with non-responders, using RNA sequencing. Finally, numerous miRNAs, mRNAs and lncRNAs were identified to be associated with the response to NACT in patients with AGC, and it was validated in an independent cohort with promising AUC values. Furthermore, we established a 6-exosome-RNA panel that could robustly identified responders from non-responders treated with fluorouracil-based neoadjuvant chemotherapy.
引用
收藏
页数:6
相关论文
共 10 条
  • [1] Gastric Cancer, Version 3.2016
    Ajani, Jaffer A.
    D'Amico, Thomas A.
    Almhanna, Khaldoun
    Bentrem, David J.
    Chao, Joseph
    Das, Prajnan
    Denlinger, Crystal S.
    Fanta, Paul
    Farjah, Farhood
    Fuchs, Charles S.
    Gerdes, Hans
    Gibson, Michael
    Glasgow, Robert E.
    Hayman, James A.
    Hochwald, Steven
    Hofstetter, Wayne L.
    Ilson, David H.
    Jaroszewski, Dawn
    Johung, Kimberly L.
    Keswani, Rajesh N.
    Kleinberg, Lawrence R.
    Korn, W. Michael
    Leong, Stephen
    Linn, Catherine
    Lockhart, A. Craig
    Ly, Quan P.
    Mulcahy, Mary F.
    Orringer, Mark B.
    Perry, Kyle A.
    Poultsides, George A.
    Scott, Walter J.
    Strong, Vivian E.
    Washington, Mary Kay
    Weksler, Benny
    Willett, Christopher G.
    Wright, Cameron D.
    Zelman, Debra
    McMillian, Nicole
    Sundar, Hema
    [J]. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2016, 14 (10): : 1286 - 1312
  • [2] Comprehensive molecular characterization of gastric adenocarcinoma
    Bass, Adam J.
    Thorsson, Vesteinn
    Shmulevich, Ilya
    Reynolds, Sheila M.
    Miller, Michael
    Bernard, Brady
    Hinoue, Toshinori
    Laird, Peter W.
    Curtis, Christina
    Shen, Hui
    Weisenberger, Daniel J.
    Schultz, Nikolaus
    Shen, Ronglai
    Weinhold, Nils
    Keiser, David P.
    Bowlby, Reanne
    Sipahimalani, Payal
    Cherniack, Andrew D.
    Getz, Gad
    Liu, Yingchun
    Noble, Michael S.
    Pedamallu, Chandra
    Sougnez, Carrie
    Taylor-Weiner, Amaro
    Akbani, Rehan
    Lee, Ju-Seog
    Liu, Wenbin
    Mills, Gordon B.
    Yang, Da
    Zhang, Wei
    Pantazi, Angeliki
    Parfenov, Michael
    Gulley, Margaret
    Piazuelo, M. Blanca
    Schneider, Barbara G.
    Kim, Jihun
    Boussioutas, Alex
    Sheth, Margi
    Demchok, John A.
    Rabkin, Charles S.
    Willis, Joseph E.
    Ng, Sam
    Garman, Katherine
    Beer, David G.
    Pennathur, Arjun
    Raphael, Benjamin J.
    Wu, Hsin-Ta
    Odze, Robert
    Kim, Hark K.
    Bowen, Jay
    [J]. NATURE, 2014, 513 (7517) : 202 - 209
  • [3] Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes
    Cristescu, Razvan
    Lee, Jeeyun
    Nebozhyn, Michael
    Kim, Kyoung-Mee
    Ting, Jason C.
    Wong, Swee Seong
    Liu, Jiangang
    Yue, Yong Gang
    Wang, Jian
    Yu, Kun
    Ye, Xiang S.
    Do, In-Gu
    Liu, Shawn
    Gong, Lara
    Fu, Jake
    Jin, Jason Gang
    Choi, Min Gew
    Sohn, Tae Sung
    Lee, Joon Ho
    Bae, Jae Moon
    Kim, Seung Tae
    Park, Se Hoon
    Sohn, Insuk
    Jung, Sin-Ho
    Tan, Patrick
    Chen, Ronghua
    Hardwick, James
    Kang, Won Ki
    Ayers, Mark
    Dai Hongyue
    Reinhard, Christoph
    Loboda, Andrey
    Kim, Sung
    Aggarwal, Amit
    [J]. NATURE MEDICINE, 2015, 21 (05) : 449 - U217
  • [4] Gastric Cancer Association China Anti-Cancer Association, 2021, Zhonghua Wei Chang Wai Ke Za Zhi, V24, P741, DOI 10.3760/cma.j.cn.441530-20210831-00351
  • [5] Tumor mutation burden is correlated with response and prognosis in microsatellite-stable (MSS) gastric cancer patients undergoing neoadjuvant chemotherapy
    Li, Ziyu
    Jia, Yongning
    Zhu, Honglin
    Xing, Xiaofang
    Pang, Fei
    Shan, Fei
    Li, Shuangxi
    Wang, Danhua
    Zhao, Fangping
    Ma, Tonghui
    Wang, Sizhen
    Ji, Jiafu
    [J]. GASTRIC CANCER, 2021, 24 (06) : 1342 - 1354
  • [6] Multi-omics characterization of molecular features of gastric cancer correlated with response to neoadjuvant chemotherapy
    Li, Ziyu
    Gao, Xiangyu
    Peng, Xinxin
    Chen, Mei-Ju May
    Li, Zhe
    Wei, Bin
    Wen, Xianzi
    Wei, Baoye
    Dong, Yu
    Bu, Zhaode
    Wu, Aiwen
    Wu, Qi
    Tang, Lei
    Li, Zhongwu
    Liu, Yiqiang
    Zhang, Li
    Jia, Shuqin
    Zhang, Lianhai
    Shan, Fei
    Zhang, Ji
    Wu, Xiaojiang
    Ji, Xin
    Ji, Ke
    Wu, Xiaolong
    Shi, Jinyao
    Xing, Xiaofang
    Wu, Jianmin
    Lv, Guoqing
    Shen, Lin
    Ji, Xuwo
    Liang, Han
    Ji, Jiafu
    [J]. SCIENCE ADVANCES, 2020, 6 (09):
  • [7] Naples Prognostic Score Predicts Tumor Regression Grade in Resectable Gastric Cancer Treated with Preoperative Chemotherapy
    Lieto, Eva
    Auricchio, Annamaria
    Tirino, Giuseppe
    Pompella, Luca
    Panarese, Iacopo
    Del Sorbo, Giovanni
    Ferraraccio, Francesca
    De Vita, Ferdinando
    Galizia, Gennaro
    Cardella, Francesca
    [J]. CANCERS, 2021, 13 (18)
  • [8] Evaluation of circulating small extracellular vesicles derived miRNAs as biomarkers of early colon cancer: a comparison with plasma total miRNAs
    Min, Li
    Zhu, Shengtao
    Chen, Lei
    Liu, Xiang
    Wei, Rui
    Zhao, Libo
    Yang, Yuqing
    Zhang, Zheng
    Kong, Guanyi
    Li, Peng
    Zhang, Shutian
    [J]. JOURNAL OF EXTRACELLULAR VESICLES, 2019, 8 (01)
  • [9] Smyth EC, 2020, LANCET, V396, P635, DOI 10.1016/S0140-6736(20)31288-5
  • [10] Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications
    Tang, Xiao-Huan
    Guo, Ting
    Gao, Xiang-Yu
    Wu, Xiao-Long
    Xing, Xiao-Fang
    Ji, Jia-Fu
    Li, Zi-Yu
    [J]. MOLECULAR CANCER, 2021, 20 (01)