Mouse Dipeptidyl Peptidase 4 Is Not a Functional Receptor for Middle East Respiratory Syndrome Coronavirus Infection

被引：77

作者：

Cockrell, Adam S. ^{[1
]}

Peck, Kayla M. ^{[4
]}

Yount, Boyd L. ^{[2
]}

Agnihothram, Sudhakar S. ^{[2
]}

Scobey, Trevor ^{[2
]}

Curnes, Nicole R. ^{[1
]}

Baric, Ralph S. ^{[2
,3
]}

Heise, Mark T. ^{[1
,3
]}

机构：

[1] Univ N Carolina, Dept Genet, Chapel Hill, NC 27523 USA

[2] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

[3] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC USA

[4] Univ N Carolina, Dept Biol, Chapel Hill, NC USA

来源：

JOURNAL OF VIROLOGY | 2014年 / 88卷 / 09期

关键词：

MERS-COV; BINDING;

D O I：

10.1128/JVI.03764-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human dipeptidyl peptidase 4 (hDPP4) was recently identified as the receptor for Middle East respiratory syndrome coronavirus (MERS-CoV) infection, suggesting that other mammalian DPP4 orthologs may also support infection. We demonstrate that mouse DPP4 cannot support MERS-CoV infection. However, employing mouse DPP4 as a scaffold, we identified two critical amino acids (A288L and T330R) that regulate species specificity in the mouse. This knowledge can support the rational design of a mouse-adapted MERS-CoV for rapid assessment of therapeutics.

引用

页码：5195 / 5199

页数：5

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