Antigenic diversity of granulocytic Ehrlichia isolates from humans in Wisconsin and New York and a horse in California

被引：102
作者：
Asanovich, KM
Bakken, JS
Madigan, JE
AgueroRosenfeld, M
Wormser, GP
Dumler, JS
机构：
[1] JOHNS HOPKINS MED INST, DEPT PATHOL, DIV MED MICROBIOL, BALTIMORE, MD 21287 USA
[2] DULUTH CLIN, INFECT DIS SECT, DULUTH, MN USA
[3] UNIV CALIF DAVIS, SCH VET MED, DEPT MED & EPIDEMIOL, DAVIS, CA USA
[4] NEW YORK MED COLL, DEPT PATHOL, VALHALLA, NY 10595 USA
[5] NEW YORK MED COLL, DIV INFECT DIS, DEPT MED, VALHALLA, NY 10595 USA
[6] WESTCHESTER CTY MED CTR, VALHALLA, NY 10595 USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 1997年 / 176卷 / 04期
关键词：
D O I：
10.1086/516529
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The agent of human granulocytic ehrlichiosis (HGE), Ehrlichia phagocytophila, and Ehrlichia equi are very similar. HGE is of variable severity. Genetic and antigenic differences among 3 human isolates (Webster, Spooner, and NY-8) and 1 horse isolate (MRK) were evaluated. The 16S rRNA gene sequences were identical in all human isolates. By use of 5 homologous antisera from these 3 humans and I horse and an additional 5 antisera in heterologous reactions, the immunodominant antigens of each isolate were noted to differ in molecular size: 43 kDa in the Webster (Wisconsin) isolate, 46 kDa in the Spooner (Wisconsin) isolate, 42 and 45 kDa in the NY-8 (New York State) isolate, and a 42 kDa doublet in the E. equi MRK isolate from California. Two sera from a Wisconsin patient reacted weakly or not at all with the NY-8 isolate. Antigenic structural diversity exists among otherwise indistinguishable granulocytic ehrlichial isolates.
引用
收藏
页码：1029 / 1034
页数：6
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