The microRNA signatures: aberrantly expressed microRNAs in head and neck squamous cell carcinoma

被引：42
作者：
Koshizuka, Keiichi [1 ,2 ]
Hanazawa, Toyoyuki [2 ]
Fukumoto, Ichiro [1 ,2 ]
Kikkawa, Naoko [2 ]
Okamoto, Yoshitaka [2 ]
Seki, Naohiko [1 ]
机构：
[1] Chiba Univ, Dept Funct Genom, Grad Sch Med, Chiba, Japan
[2] Chiba Univ, Dept Otorhinolaryngol Head & Neck Surg, Grad Sch Med, Chiba, Japan
来源：
JOURNAL OF HUMAN GENETICS | 2017年 / 62卷 / 01期
关键词：
NASOPHARYNGEAL CARCINOMA; TUMOR-SUPPRESSOR; INHIBITS PROLIFERATION; DNA HYPERMETHYLATION; GENOMIC ALTERATIONS; MOLECULAR-BIOLOGY; MESSENGER-RNA; C-MYC; CANCER; INVASION;
D O I：
10.1038/jhg.2016.105
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
microRNAs (miRNAs) are responsible for fine tuning the normal expression of RNA networks in human cells. Accumulating studies have demonstrated that abnormally expressed miRNAs have pivotal roles in the development of head and neck squamous cell carcinoma (HNSCC). Specifically, expression signatures of miRNAs in HNSCC have revealed dysregulated production of miRNAs and the resultant abnormal production of mRNAs and proteins. In this review, we discuss current findings regarding aberrantly expressed miRNAs and their contribution to HNSCC molecular pathogenesis.
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页码：3 / 13
页数：11
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