Hypoxia and cancer cell metabolism

被引：64

作者：

Huang, De ^{[1
]}

Li, Chenchen ^{[1
]}

Zhang, Huafeng ^{[1
]}

机构：

[1] Univ Sci & Technol China, Sch Life Sci, Innovat Ctr Cell Biol, Hefei 230027, Peoples R China

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2014年 / 46卷 / 03期

基金：

中国国家自然科学基金;

关键词：

hypoxia; HIF-1; cancer; metabolism; INDUCIBLE FACTOR-I; GLUTAMINE-METABOLISM; REDUCTIVE CARBOXYLATION; C-MYC; HIF-1; GENE; GROWTH; DEHYDROGENASE; ACTIVATION; PROTEIN;

D O I：

10.1093/abbs/gmt148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The past decade has witnessed a rapid accumulation of evidence showing that hypoxic microenvironment, which is typical during cancer development, plays key roles in regulating cancer cell metabolism. In this review, we will focus on the role of hypoxic response, particularly, its master regulator hypoxia-inducible factor-1, in regulating glucose, lipid, as well as amino acid metabolism in cancer cells. We will also discuss the therapeutic opportunities by targeting specific pathways that facilitate metabolic reprogramming in cancer cells.

引用

页码：214 / 219

页数：6

共 60 条

[41]

SAMID D, 1992, BLOOD, V80, P1576

[42] Lipid metabolism in cancer [J].

Santos, Claudio R. ;

Schulze, Almut .

FEBS JOURNAL, 2012, 279 (15) :2610-2623

[43] Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics [J].

Semenza, G. L. .

ONCOGENE, 2010, 29 (05) :625-634

[44] A NUCLEAR FACTOR INDUCED BY HYPOXIA VIA DENOVO PROTEIN-SYNTHESIS BINDS TO THE HUMAN ERYTHROPOIETIN GENE ENHANCER AT A SITE REQUIRED FOR TRANSCRIPTIONAL ACTIVATION [J].

SEMENZA, GL ;

WANG, GL .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (12) :5447-5454

[45] Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1 [J].

Semenza, GL ;

Jiang, BH ;

Leung, SW ;

Passantino, R ;

Concordet, JP ;

Maire, P ;

Giallongo, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (51) :32529-32537

[46]

SEMENZA GL, 1994, J BIOL CHEM, V269, P23757

[47] Targeting HIF-1 for cancer therapy [J].

Semenza, GL .

NATURE REVIEWS CANCER, 2003, 3 (10) :721-732

[48] Hypoxia-Inducible Factors in Physiology and Medicine [J].

Semenza, Gregg L. .

CELL, 2012, 148 (03) :399-408

[49] Coming up for air: HF-1 and mitochondrial oxygen consumption [J].

Simon, MC .

CELL METABOLISM, 2006, 3 (03) :150-151

[50] Hypoxia upregulates amino acid transport in a human neuroblastoma cell line [J].

Soh, Hideki ;

Wasa, Masafumi ;

Fukuzawa, Masahiro .

JOURNAL OF PEDIATRIC SURGERY, 2007, 42 (04) :608-612

← 1 2 3 4 5 6 →