Hypoxia and cancer cell metabolism

被引：64

作者：

Huang, De ^{[1
]}

Li, Chenchen ^{[1
]}

Zhang, Huafeng ^{[1
]}

机构：

[1] Univ Sci & Technol China, Sch Life Sci, Innovat Ctr Cell Biol, Hefei 230027, Peoples R China

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2014年 / 46卷 / 03期

基金：

中国国家自然科学基金;

关键词：

hypoxia; HIF-1; cancer; metabolism; INDUCIBLE FACTOR-I; GLUTAMINE-METABOLISM; REDUCTIVE CARBOXYLATION; C-MYC; HIF-1; GENE; GROWTH; DEHYDROGENASE; ACTIVATION; PROTEIN;

D O I：

10.1093/abbs/gmt148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The past decade has witnessed a rapid accumulation of evidence showing that hypoxic microenvironment, which is typical during cancer development, plays key roles in regulating cancer cell metabolism. In this review, we will focus on the role of hypoxic response, particularly, its master regulator hypoxia-inducible factor-1, in regulating glucose, lipid, as well as amino acid metabolism in cancer cells. We will also discuss the therapeutic opportunities by targeting specific pathways that facilitate metabolic reprogramming in cancer cells.

引用

页码：214 / 219

页数：6

共 60 条

[1] A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth [J].

Bonnet, Sebastien ;

Archer, Stephen L. ;

Allalunis-Turner, Joan ;

Haromy, Alois ;

Beaulieu, Christian ;

Thompson, Richard ;

Lee, Christopher T. ;

Lopaschuk, Gary D. ;

Puttagunta, Lakshmi ;

Bonnet, Sandra ;

Harry, Gwyneth ;

Hashimoto, Kyoko ;

Porter, Christopher J. ;

Andrade, Miguel A. ;

Thebaud, Bernard ;

Michelakis, Evangelos D. .

CANCER CELL, 2007, 11 (01) :37-51

[2] Cancer metabolism: fatty acid oxidation in the limelight [J].

Carracedo, Arkaitz ;

Cantley, Lewis C. ;

Pandolfi, Pier Paolo .

NATURE REVIEWS CANCER, 2013, 13 (04) :227-232

[3] MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2 [J].

Chan, Stephen Y. ;

Zhang, Ying-Yi ;

Hemann, Craig ;

Mahoney, Christopher E. ;

Zweier, Jay L. ;

Loscalzo, Joseph .

CELL METABOLISM, 2009, 10 (04) :273-284

[4] Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression [J].

Chen, Z. ;

Li, Y. ;

Zhang, H. ;

Huang, P. ;

Luthra, R. .

ONCOGENE, 2010, 29 (30) :4362-4368

[5] Cellular Fatty Acid Metabolism and Cancer [J].

Currie, Erin ;

Schulze, Almut ;

Zechner, Rudolf ;

Walther, Tobias C. ;

Farese, Robert V., Jr. .

CELL METABOLISM, 2013, 18 (02) :153-161

[6] Expansion of human SCID-repopulating cells under hypoxic conditions [J].

Danet, GH ;

Pan, Y ;

Luongo, JL ;

Bonnet, DA ;

Simon, MC .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (01) :126-135

[7] Oncogenic alterations of metabolism [J].

Dang, CV ;

Semenza, GL .

TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (02) :68-72

[8]

De Bels D, 2011, NEW ENGL J MED, V365, P1845, DOI [10.1056/NEJMra1011165, 10.1056/NEJMc1110602]

[9] Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer [J].

DeBerardinis, R. J. ;

Cheng, T. .

ONCOGENE, 2010, 29 (03) :313-324

[10] Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis [J].

DeBerardinis, Ralph J. ;

Mancuso, Anthony ;

Daikhin, Evgueni ;

Nissim, Ilana ;

Yudkoff, Marc ;

Wehrli, Suzanne ;

Thompson, Craig B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (49) :19345-19350

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