Preparation of conjugated 1,3-enynes by Rh(III)-catalysed alkynylation of alkenes via C-H activation

被引：163

作者：

Collins, Karl D. ^{[1
]}

Lied, Fabian ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 34期

基金：

欧洲研究理事会;

关键词：

CATALYZED DIRECT ALKYNYLATION; ROBUSTNESS SCREEN; RAPID ASSESSMENT; GOLD; ALKYNES; CYCLOISOMERIZATION; BONDS; EBX; FUNCTIONALIZATION; ETHYNYLATION;

D O I：

10.1039/c4cc01141d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An experimentally simple additive-free Rh(III)-catalysed direct alkynylation of alkenes has been developed. This protocol employs commercially available TIPS-EBX as the alkyne source, giving access to conjugated terminal enynes following a simple silyl-deprotection. This method has also been applied to arenes.

引用

页码：4459 / 4461

页数：3

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