DNA hybridization at the air-water interface

被引：36
|
作者：
Ebara, Y [1 ]
Mizutani, K [1 ]
Okahata, Y [1 ]
机构：
[1] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 2268501, Japan
来源：
LANGMUIR | 2000年 / 16卷 / 06期
关键词：
D O I：
10.1021/la991189z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We observed, by using a quartz crystal microbalance, linear oligonucleotides binding selectively to the planar nucleobase lipid monolayer at the air-water interface and hybridization between two linear oligonucleotides in aqueous solution. Kinetics of DNA hybridization at the interface could be controlled by changing the distance and orientation between nucleobases in the monolayer and compared with those for conventional hybridization in the aqueous solution.
引用
收藏
页码：2416 / 2418
页数：3
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