ABO incompatibility does not influence transfusion requirements in patients undergoing single-unit umbilical cord blood transplantation

被引：11

作者：

Solves, P. ^{[1
]}

Carpio, N. ^{[1
]}

Carretero, C. ^{[1
]}

Lorenzo, J. I. ^{[1
]}

Sanz, J. ^{[1
]}

Gomez, I. ^{[1
]}

Lopez-Chulia, F. ^{[1
]}

Arilla, M. J. ^{[1
]}

Regadera, A. I. ^{[1
]}

Montesinos, P. ^{[1
]}

Sanz, G. F. ^{[1
]}

Sanz, M. A. ^{[1
]}

机构：

[1] Hosp Univ & Politecn La Fe Avda Abril Martorell, Blood Bank, Valencia 46026, Spain

来源：

BONE MARROW TRANSPLANTATION | 2017年 / 52卷 / 03期

关键词：

STEM-CELL TRANSPLANTATION; PLATELET TRANSFUSION; IMPACT; HEMOLYSIS; DONOR; EXPERIENCE;

D O I：

10.1038/bmt.2016.264

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Hematopoietic stem cell transplantation is usually performed without considering the ABO compatibility between donor and recipient. There are few studies analyzing ABO matching impact on transfusion outcome of umbilical cord blood transplantation (UCBT) recipients. The aim of this study was to analyze factors influencing transfusion outcome, highlighting the ABO matching between donor and recipient. This study has reviewed data from 318 patients who underwent single unit UCBT at la Fe University Hospital from January 2000 to December 2014. There were no differences between RBC and platelet (PLT) requirements or RBC and PLT transfusion independence according to ABO matching between donor and recipient. RBC and PLT requirements were statistically correlated (rho = 0,841, Po0.001). A total of 170 and 188 patients achieved RBC and PLT independence, respectively, within 180 days after UCBT. Persistence of recipient isoagglutinins was detected in 6.8% of patients with major ABO incompatibility at median of 176 days (103-269) after UCBT. Autoimmune haemolytic anemia was diagnosed in 15 patients, 12 of them due to cold antibodies. In conclusion, ABO matching has not influenced transfusion requirements of patients undergoing UCBT.

引用

页码：394 / 399

页数：6

共 26 条

[11] Effect of ABO Blood Group Incompatibility on the Outcome of Single-Unit Cord Blood Transplantation after Myeloablative Conditioning [J].

Konuma, Takaaki ;

Kato, Seiko ;

Ooi, Jun ;

Oiwa-Monna, Maki ;

Ebihara, Yasuhiro ;

Mochizuki, Shinji ;

Yuji, Koichiro ;

Ohno, Nobuhiro ;

Kawamata, Toyotaka ;

Jo, Norihide ;

Yokoyama, Kazuaki ;

Uchimaru, Kaoru ;

Tojo, Arinobu ;

Takahashi, Satoshi .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2014, 20 (04) :577-581

[12] Red cell and platelet transfusion burden following myeloablative allogeneic haemopoietic stem cell transplantation [J].

Le Viellez, A. ;

P'Ng, S. ;

Buffery, S. ;

Wright, M. ;

Cooney, J. ;

Cannell, P. ;

Purtill, D. .

INTERNAL MEDICINE JOURNAL, 2015, 45 (12) :1286-1292

[13] Concise Review: Umbilical Cord Blood Transplantation: Past, Present, and Future [J].

Munoz, Javier ;

Shah, Nina ;

Bezvani, Katayoun ;

Hosing, Chitra ;

Bollard, Catherine M. ;

Oran, Betul ;

Olson, Amanda ;

Popat, Uday ;

Molldrem, Jeffrey ;

Mcniece, Ian K. ;

Shpall, Elizabeth J. .

STEM CELLS TRANSLATIONAL MEDICINE, 2014, 3 (12) :1435-1443

[14] Impact of ABO-Incompatible Donor on Early and Late Outcome of Hematopoietic Stem Cell Transplantation [J].

Ozkurt, Z. N. ;

Yegin, Z. A. ;

Yenicesu, I. ;

Aki, S. Z. ;

Yagci, M. ;

Sucak, G. T. .

TRANSPLANTATION PROCEEDINGS, 2009, 41 (09) :3851-3858

[15] Immune hemolysis associated with transplantation [J].

Petz, LD .

SEMINARS IN HEMATOLOGY, 2005, 42 (03) :145-155

[16] Red blood cell-incompatible allogeneic hematopoietic progenitor cell transplantation [J].

Rowley, S. D. ;

Donato, M. L. ;

Bhattacharyya, P. .

BONE MARROW TRANSPLANTATION, 2011, 46 (09) :1167-1185

[17] Delayed massive immune hemolysis mediated by minor ABO incompatibility after allogeneic peripheral blood progenitor cell transplantation [J].

Salmon, JP ;

Michaux, S ;

Hermanne, JP ;

Baudoux, E ;

Gérard, C ;

Sontag-Thull, D ;

Fillet, G ;

Beguin, Y .

TRANSFUSION, 1999, 39 (08) :824-827

[18] Autoimmune cytopenias after umbilical cord blood transplantation in adults with hematological malignancies: a single-center experience [J].

Sanz, J. ;

Arango, M. ;

Carpio, N. ;

Montesinos, P. ;

Moscardo, F. ;

Martin, G. ;

Lopez, F. ;

Jarque, I. ;

Lorenzo, I. ;

de la Rubia, J. ;

Solves, P. ;

Boluda, B. ;

Salazar, C. ;

Canigral, C. ;

Sanz, M. A. ;

Sanz, G. F. .

BONE MARROW TRANSPLANTATION, 2014, 49 (08) :1084-1088

[19] Cord Blood Transplantation from Unrelated Donors in Adults with High-Risk Acute Myeloid Leukemia [J].

Sanz, Jaime ;

Sanz, Miguel A. ;

Saavedra, Silvana ;

Lorenzo, Ignacio ;

Montesinos, Pau ;

Senent, Leonor ;

Planelles, Dolores ;

Larrea, Luis ;

Martin, Guillermo ;

Palau, Javier ;

Jarque, Isidro ;

Martinez, Jesus ;

de la Rubia, Javier ;

Moscardo, Federico ;

Romero, Monica ;

Luna, Irene ;

Montava, Alberto ;

Canabate, Sergio ;

Sanz, Guillermo F. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (01) :86-94

[20] Lack of isohemagglutinin production following minor ABO incompatible unrelated HLA mismatched umbilical cord blood transplantation [J].

Snell, M. ;

Chau, C. ;

Hendrix, D. ;

Fox, R. ;

Downes, K. A. ;

Creger, R. ;

Meyerson, H. ;

Telen, M. J. ;

Laughlin, M. J. ;

Lazarus, H. M. ;

Yomtovian, R. .

BONE MARROW TRANSPLANTATION, 2006, 38 (02) :135-140

← 1 2 3 →