The Cellular Prion Protein: A Promising Therapeutic Target for Cancer

被引：23

作者：

Go, Gyeongyun ^{[1
]}

Lee, Sang Hun ^{[1
,2
]}

机构：

[1] Soonchunhyang Univ, Coll Med, Dept Biochem, Cheonan 31151, South Korea

[2] Soonchunhyang Univ, Seoul Hosp, Med Sci Res Inst, Seoul 04401, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 23期

基金：

新加坡国家研究基金会;

关键词：

cellular prion protein; PrP(C); PRNP; cancer; cancer stem cell; targeted cancer therapy;

D O I：

10.3390/ijms21239208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies on the cellular prion protein (PrP(C)) have been actively conducted because misfolded PrP(C) is known to cause transmissible spongiform encephalopathies or prion disease. PrP(C) is a glycophosphatidylinositol-anchored cell surface glycoprotein that has been reported to affect several cellular functions such as stress protection, cellular differentiation, mitochondrial homeostasis, circadian rhythm, myelin homeostasis, and immune modulation. Recently, it has also been reported that PrP(C) mediates tumor progression by enhancing the proliferation, metastasis, and drug resistance of cancer cells. In addition, PrP(C) regulates cancer stem cell properties by interacting with cancer stem cell marker proteins. In this review, we summarize how PrP(C) promotes tumor progression in terms of proliferation, metastasis, drug resistance, and cancer stem cell properties. In addition, we discuss strategies to treat tumors by modulating the function and expression of PrP(C) via the regulation of HSPA1L/HIF-1 alpha expression and using an anti-prion antibody.

引用

页码：1 / 14

页数：14

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