Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors

被引：27
作者：
Yasumo, H [1 ]
Masuda, N [1 ]
Furusawa, T [1 ]
Tsukamoto, T [1 ]
Sadano, H [1 ]
Osumi, T [1 ]
机构：
[1] Himeji Inst Technol, Dept Life Sci, Kamigori, Hyogo 6781297, Japan
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2000年 / 1490卷 / 1-2期
关键词：
peroxisome proliferator-activated receptor; two-hybrid system; protein-protein interaction; coactivator; corepressor;
D O I：
10.1016/S0167-4781(99)00244-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A protein named nuclear receptor binding factor-2 (NRBF-2) was identified by yeast two-hybrid screening, as an interaction partner of peroxisome proliferator-activated receptor a as well as several other nuclear receptors. NRBF-2 exhibited a gene activation function, when tethered to a heterologous DNA binding domain, in both mammalian cells and yeast. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：189 / 197
页数：9
相关论文
共 33 条
  • [1] Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
    Alland, L
    Muhle, R
    Hou, H
    Potes, J
    Chin, L
    SchreiberAgus, N
    DePinho, RA
    [J]. NATURE, 1997, 387 (6628) : 49 - 55
  • [2] An adipogenic cofactor bound by the differentiation domain of PPARγ
    Castillo, G
    Brun, RP
    Rosenfield, JK
    Hauser, S
    Park, CW
    Troy, AE
    Wright, ME
    Spiegelman, BM
    [J]. EMBO JOURNAL, 1999, 18 (13) : 3676 - 3687
  • [3] Role of CBP/P300 in nuclear receptor signalling
    Chakravarti, D
    LaMorte, VJ
    Nelson, MC
    Nakajima, T
    Schulman, IG
    Juguilon, H
    Montminy, M
    Evans, RM
    [J]. NATURE, 1996, 383 (6595) : 99 - 103
  • [4] A TRANSCRIPTIONAL CO-REPRESSOR THAT INTERACTS WITH NUCLEAR HORMONE RECEPTORS
    CHEN, JD
    EVANS, RM
    [J]. NATURE, 1995, 377 (6548) : 454 - 457
  • [5] Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha
    Chu, RY
    Lin, YL
    Rao, MS
    Reddy, JK
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (44) : 27670 - 27676
  • [6] p300 functions as a coactivator for the peroxisome proliferator-activated receptor α
    Dowell, P
    Ishmael, JE
    Avram, D
    Peterson, VJ
    Nevrivy, DJ
    Leid, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (52) : 33435 - 33443
  • [7] A signature motif in transcriptional co-activators mediates binding to nuclear receptor
    Heery, DM
    Kalkhoven, E
    Hoare, S
    Parker, MG
    [J]. NATURE, 1997, 387 (6634) : 733 - 736
  • [8] GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
    Hong, H
    Kohli, K
    Trivedi, A
    Johnson, DL
    Stallcup, MR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (10) : 4948 - 4952
  • [9] LIGAND-INDEPENDENT REPRESSION BY THE THYROID-HORMONE RECEPTOR-MEDIATED BY A NUCLEAR RECEPTOR CO-REPRESSOR
    HORLEIN, AJ
    NAAR, AM
    HEINZEL, T
    TORCHIA, J
    GLOSS, B
    KUROKAWA, R
    RYAN, A
    KAMEL, Y
    SODERSTROM, M
    GLASS, CK
    ROSENFELD, MG
    [J]. NATURE, 1995, 377 (6548) : 397 - 404
  • [10] PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
    Jiang, CY
    Ting, AT
    Seed, B
    [J]. NATURE, 1998, 391 (6662) : 82 - 86
1234