Clinical Epigenetics of Neuroendocrine Tumors: The Road Ahead

被引：34

作者：

Colao, Annamaria ^{[1
]}

de Nigris, Filomena ^{[2
]}

Modica, Roberta ^{[3
]}

Napoli, Claudio ^{[4
]}

机构：

[1] Federico II Univ Naples, Dept Clin Med & Surg, Unesco Chair Hlth Educ & Sustainable Dev, Naples, Italy

[2] Univ Campania Luigi Vanvitelli, Dept Precis Med, Naples, Italy

[3] Federico II Univ Naples, Dept Clin Med & Surg, Naples, Italy

[4] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy

来源：

FRONTIERS IN ENDOCRINOLOGY | 2020年 / 11卷

关键词：

epigenetics; neuroendocrine neoplasms; trials; biomarkers; neuroendocrine; neuroendocrine tumor; CIRCULATING TRANSCRIPT ANALYSIS; DNA METHYLATION; PANCREATIC ENDOCRINE; MICRORNA EXPRESSION; PROGNOSTIC RELEVANCE; GERMLINE MUTATION; CARCINOID-TUMORS; DOWN-REGULATION; THERAPY; CANCER;

D O I：

10.3389/fendo.2020.604341

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neuroendocrine tumors, or NETs, are cancer originating in neuroendocrine cells. They are mostly found in the gastrointestinal tract or lungs. Functional NETs are characterized by signs and symptoms caused by the oversecretion of hormones and other substances, but most NETs are non-functioning and diagnosis in advanced stages is common. Thus, novel diagnostic and therapeutic strategies are warranted. Epigenetics may contribute to refining the diagnosis, as well as to identify targeted therapy interfering with epigenetic-sensitive pathways. The goal of this review was to discuss the recent advancement in the epigenetic characterization of NETs highlighting their role in clinical findings.

引用

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