The Clinical Use of Biologics in the Knee Lesions: Does the Patient Benefit?

被引:11
作者
Cengiz, Ibrahim Fatih [1 ,2 ]
Pereira, Helder [1 ,2 ,3 ,4 ]
Espregueira-Mendes, Joao [1 ,2 ,5 ,6 ,7 ]
Reis, Rui L. [1 ,2 ,8 ]
Oliveira, Joaquim Miguel [1 ,2 ,8 ]
机构
[1] Univ Minho, Headquarters European Inst Excellence Tissue Engn, I3Bs Res Inst Biomat Biodegradables & Biomimet, 3Bs Res Grp, AvePk,Parque Ciencia & Tecnol, P-4805017 Barco, Guimaraes, Portugal
[2] ICVS 3Bs PT Govt Associate Lab, Braga, Guimaraes, Portugal
[3] Murcia Madrid FIFA Med Ctr Excellence, Ripoll & De Prado Sports Clin, Madrid, Spain
[4] Ctr Hosp Povoa Varzim, Orthoped Dept, Vila Do Conde, Portugal
[5] FIFA Med Ctr Excellence, Espregueira Mendes Sports Ctr, Clin Dragao, Porto, Portugal
[6] Dom Henrique Res Ctr, Porto, Portugal
[7] Univ Minho, Orthoped Dept, Braga, Portugal
[8] Headquarters Univ Minho, Discoveries Ctr Regenerat & Precis Med, AvePk, P-4805017 Barco, Guimaraes, Portugal
关键词
Platelet-rich plasma; Knee; Osteoarthritis; Meniscus; Ligament; Biologics; PLATELET-RICH PLASMA; HYALURONIC-ACID; DOUBLE-BLIND; INTRAARTICULAR INJECTION; GROWTH-FACTORS; OSTEOARTHRITIS; REPAIR; PRP; PLACEBO; SINGLE;
D O I
10.1007/s12178-019-09573-3
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Purpose of Review Overview the outcomes of the latest use of platelet-rich plasma (PRP) for the treatment of knee lesions in the clinics and discuss the challenges and limitations. Recent Findings Recent clinical studies mainly indicate there may be benefit of PRP usage for the treatment of knee lesions. As an autologous source of bioactive components, PRP has been shown to be typically safe, free of major adverse outcomes. The use of PRP has been continuously increasing, and some well-designed, double-blinded, placebo-controlled clinical trials have been published. Clinical outcomes relating to PRP usage are multifactorial and depend on the severity of the lesion and patient characteristics. Although PRP is safe to use and it can be easily applied in the clinics, case-specific considerations are needed to determine whether PRP could be beneficial or not. If the use of PRP is favored, then, the configuration/optimization of the preparation and administration/delivery strategy with or without a concomitant treatment may further enhance the clinical outcomes and patients' experience.
引用
收藏
页码:406 / 414
页数:9
相关论文
共 76 条
[1]   Clinical outcomes are associated with changes in ultrasonographic structural appearance after platelet-rich plasma treatment for knee osteoarthritis [J].
Ahmad, Hamada S. ;
Farrag, Sherief E. ;
Okasha, Amr E. ;
Kadry, Aisha O. ;
Ata, Tamer B. ;
Monir, Amir A. ;
Shady, Ibrahim .
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2018, 21 (05) :960-966
[2]   Platelet-rich plasma for managing pain and inflammation in osteoarthritis [J].
Andia, Isabel ;
Maffulli, Nicola .
NATURE REVIEWS RHEUMATOLOGY, 2013, 9 (12) :721-730
[3]   Intra-articular injections of expanded mesenchymal stem cells with and without addition of platelet-rich plasma are safe and effective for knee osteoarthritis [J].
Bastos, Ricardo ;
Mathias, Marcelo ;
Andrade, Renato ;
Bastos, Raquel ;
Balduino, Alex ;
Schott, Vinicius ;
Rodeo, Scott ;
Espregueira-Mendes, Joao .
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 2018, 26 (11) :3342-3350
[4]   What techniques might be used to harness placebo effects in non-malignant pain? A literature review and survey to develop a taxonomy [J].
Bishop, Felicity L. ;
Coghlan, Beverly ;
Geraghty, Adam W. A. ;
Everitt, Hazel ;
Little, Paul ;
Holmes, Michelle M. ;
Seretis, Dionysis ;
Lewith, George .
BMJ OPEN, 2017, 7 (06)
[5]   Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomized controlled trial [J].
Buendia-Lopez, David ;
Medina-Quiros, Manuel ;
Fernandez-Villacanas Marin, Miguel Angel .
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY, 2018, 19 (01)
[6]  
Camurcu Y, 2018, J BACK MUSCULOSKELET, P1
[7]   Comparison of Growth Factor and Platelet Concentration From Commercial Platelet-Rich Plasma Separation Systems [J].
Castillo, Tiffany N. ;
Pouliot, Michael A. ;
Kim, Hyeon Joo ;
Dragoo, Jason L. .
AMERICAN JOURNAL OF SPORTS MEDICINE, 2011, 39 (02) :266-271
[8]  
Cengiz, 2017, INJURIES HLTH PROBLE, P679
[9]  
Cengiz I F, 2017, INJURIES HLTH PROBLE, P145, DOI DOI 10.1007/978-3-662-53924-8_14
[10]   Orthopaedic regenerative tissue engineering en route to the holy grail: disequilibrium between the demand and the supply in the operating room [J].
Cengiz I.F. ;
Pereira H. ;
de Girolamo L. ;
Cucchiarini M. ;
Espregueira-Mendes J. ;
Reis R.L. ;
Oliveira J.M. .
Journal of Experimental Orthopaedics, 5 (1)