Alpha particle vascular brachytherapy in the treatment of in-stent Restenosis

被引：1

作者：

Mehdizadeh, Alireza ^{[1
]}

Fazelzadeh, Afsoon ^{[1
]}

Karimi, Hamed ^{[1
]}

机构：

[1] Mashad Univ Med Sci, Sch Med, Dept Med Phys, Mashhad, Iran

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2009年 / 136卷 / 02期

关键词：

Stent; Restenosis; Coronary artery disease; Vascular brachytherapy; Boron Neutron Capture Therapy; Alpha particle;

D O I：

10.1016/j.ijcard.2008.04.036

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In-stent Restenosis (ISR) is the Achilles heel for using of stent. Vascular brachytherapy (VBT) has been the principal scientifically investigated local therapy for coronary artery ISR. In our suggested method, a new type of stent, which is coated with Boron (10B) compound, is used. The coating layer of the stent consists of stable isotype of 10B. Boron Neutron Capture Therapy produced alpha particle has enough energy to kill the cells adjacent to the stent, which is the site of boron deposition. It would prevent from ISR and intimal proliferation. After percutaneous coronary intervention (PCI) and insertion of stent, follow-up should be done continuously, and if ISR is detected, BNCT will be used to treat the recurrence. Using this modality of VBT would help us to overcome the pitfalls in en vogue radiotherapy methods. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：220 / 221

页数：2

共 5 条

[1] Late coronary occlusion after intracoronary brachytherapy [J].

Costa, MA ;

Sabaté, M ;

van der Giessen, WJ ;

Kay, IP ;

Cervinka, P ;

Ligthart, JMR ;

Serrano, P ;

Coen, VLMA ;

Levendag, PC ;

Serruys, PW .

CIRCULATION, 1999, 100 (08) :789-792

[2] Five-year clinical follow-up after intracoronary radiation - Results of a randomized clinical trial [J].

Grise, MA ;

Massullo, V ;

Jani, S ;

Popma, JJ ;

Russo, RJ ;

Schatz, RA ;

Guarneri, EM ;

Steuterman, S ;

Cloutier, DA ;

Leon, MB ;

Tripuraneni, P ;

Teirstein, PS .

CIRCULATION, 2002, 105 (23) :2737-2740

[3] Long-term clinical outcome of patients treated with β-brachytherapy in routine clinical practice [J].

Nikas, Dimitrios N. ;

Kalef-Ezra, John ;

Katsouras, Christos S. ;

Tsekeris, Periklis ;

Bozios, George ;

Pappas, Christos ;

Naka, Katerina K. ;

Kotsia, Anna ;

Papamichael, Nikolaos ;

Sideris, Dimitrios A. ;

Michalis, Lampros K. .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2007, 115 (02) :183-189

[4] A meta-analysis of randomised controlled trials assessing drug-eluting stents and vascular brachytherapy in the treatment of coronary artery in-stent restenosis [J].

Oliver, Lisa N. ;

Buttner, Petra G. ;

Hobson, Helen ;

Golledge, Jonathan .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2008, 126 (02) :216-223

[5] Is this the swan song of endovascular brachytherapy? [J].

Van Limbergen, Erik ;

Trepuraneni, Prabhakar .

RADIOTHERAPY AND ONCOLOGY, 2007, 82 (01) :1-4

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