Prevalence of Sinusitis Detected by Magnetic Resonance Imaging in Subjects with Dementia or Alzheimer's Disease

被引:12
作者
Yasue, Minori [1 ,2 ]
Sugiura, Saiko [1 ]
Uchida, Yasue [1 ,3 ,4 ]
Otake, Hironao [5 ,6 ]
Teranishi, Masaaki [6 ]
Sakurai, Takashi [7 ]
Toba, Kenji [7 ]
Shimokata, Hiroshi [4 ,8 ]
Ando, Fujiko [4 ,9 ]
Otsuka, Rei [4 ]
Nakashima, Tsutomu [1 ,6 ]
机构
[1] Natl Ctr Geriatr & Gerontol, Dept Otorhinolaryngol, Obu City 4740038, Japan
[2] Kamiiida Daiichi Gen Hosp, Dept Otorhinolaryngol, Nagoya, Aichi, Japan
[3] Aichi Med Univ, Dept Otorhinolaryngol, Nagakute, Aichi 48011, Japan
[4] Natl Ctr Geriatr & Gerontol, Sect NILS LSA, Obu, Japan
[5] Nagoya Univ, Grad Sch Med, Dept Sleep Med, Nagoya, Aichi 4648601, Japan
[6] Nagoya Univ, Grad Sch Med, Dept Otorhinolaryngol, Nagoya, Aichi 4648601, Japan
[7] Natl Ctr Geriatr & Gerontol, Ctr Comprehens Care & Res Memory Disorders, Obu, Japan
[8] Nagoya Univ Arts & Sci, Grad Sch Nutr Sci, Nisshin, Japan
[9] Aichi Shukutoku Univ, Dept Hlth & Med Sci, Nagoya, Aichi, Japan
关键词
Alzheimer's disease; dementia; Lund-Mackey scoring system; magnetic resonance imaging; mini-mental state examination; MILD COGNITIVE IMPAIRMENT; ORAL-HEALTH; TOOTH LOSS; CHRONIC RHINOSINUSITIS; ASPIRATION PNEUMONIA; APOLIPOPROTEIN-E; RISK-FACTORS; IDENTIFICATION; DECLINE; COMPLICATIONS;
D O I
10.2174/1567205012666150710105152
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: It has been reported that periodontitis is associated with Alzheimer's disease. However, the association between paranasal sinusitis and Alzheimer's disease has not been studied, although olfactory dysfunction frequently precedes the progress of dementia or Alzheimer's disease. Methods: We studied 783 patients (283 men, 500 women; mean age 77.0 +/- 7.9 years) who visited the Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, and 2139 control subjects who participated in a population-based study conducted by the National Institute for Longevity Sciences - Longitudinal Study of Aging (NILS-LSA) in Japan. Sinusitis was evaluated using magnetic resonance imaging (MRI) according to the Lund-Mackay scoring system. A sinusitis score of >= 4 was classified as positive and a score of <= 3 was classified as negative. Results: The prevalence of positive sinusitis was 6.3% in patients with a mini-mental state examination (MMSE) score of < 24 (n = 507), and 5.7% in patients with Alzheimer's disease (n = 280). The rate of positive sinusitis was7.2% in the control group. The prevalence of sinusitis was not significantly different between normal controls and patients with dementia or Alzheimer's disease after adjustments for age and sex. The rate of positive sinusitis was higher in male than in female subjects in both groups. Conclusion: The prevalence of sinusitis in patients with Alzheimer's disease or dementia was not higher than in the general population.
引用
收藏
页码:1006 / 1011
页数:6
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