Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid, as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp TJ23

被引：67

作者：

Hu, Zhengxi ^{[1
]}

Sun, Weiguang ^{[1
]}

Li, Qin ^{[1
]}

Li, Xiao-Nian ^{[1
,2
]}

Zhu, Hucheng

Huang, Jinfeng ^{[1
]}

Liu, Junjun ^{[1
]}

Wang, Jianping ^{[1
]}

Xue, Yongbo ^{[1
]}

Zhang, Yonghui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 06期

基金：

中国国家自然科学基金;

关键词：

BINDING PROTEIN 2A; BETA-LACTAM ANTIBIOTICS; CELL-WALL; MRSA; COMBINATIONS; INHIBITION; PBP2A;

D O I：

10.1021/acs.joc.7b00056

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bioassay-guided isolation of cultures of Aspergillus sp. TJ23 yielded a novel terpene-polyketide hybrid spiromeroterpenoid, spiroaspertrione A (1), bearing a unique spiro[bicydo[3.2.2]nonane-2,1'-cyclohexane] carbocydic skeleton, and a new biointermediate, andiconin B (2). Their structures and absolute configurations were elucidated by spectroscopic analyses, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compound 1 demonstrated potent resensitization of oxacillin against methicillin-resistant Staphylococcus aureus by lowering the oxacillin minimal inhibitory concentration up to 32-fold from 32 to 1 mu g/mL.

引用

页码：3125 / 3131

页数：7

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