Tyrosinase Inhibitory Activity of a Glucosylated Hydroxystilbene in Mouse Melan-a Melanocytes

被引：32

作者：

Cheung, Florence Wing-Ki ^{[1
,2
]}

Leung, Albert Wing-Nang ^{[2
]}

Liu, Wing Keung ^{[1
]}

Che, Chun-Tao ^{[2
,3
,4
]}

机构：

[1] Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Sch Chinese Med, Shatin, Hong Kong, Peoples R China

[3] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

[4] Univ Illinois, Coll Pharm, WHO Collaborating Ctr Tradit Med, Chicago, IL 60612 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 06期

关键词：

MELANOGENESIS; KEY;

D O I：

10.1021/np4008798

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-gluco-pyranoside (1), isolated from Polygonum multiflorum, is a noncompetitive inhibitor of tyrosinase in cell-free kinetics; it reduced the V-max, values in a dose-dependent manner. Compound I inhibited PKA-induced melanogenesis, reduced the protein expression of tyrosinase and its transcription factor, the microphthalmia-associated transcription factor, and lowered the complex formation between tyrosinase and tyrosinase-related protein 1 (TRP-1). Inuminofluorescence microscopy revealed no association of tyrosinase with the endoplasmic reticulum or lysosomes, implying the absence of a direct effect of 1 on the maturation process of the enzime. The antimelanogenic activity of 1 is likely mediated through a noncompetitive inhibition on tyrosinase, down-regulation of the expression of melanogenic proteins, and reduction of tyrosinase/TRP-1 complex formation.

引用

页码：1270 / 1274

页数：5

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