Algal toxin impairs sea lion memory and hippocampal connectivity, with implications for strandings

被引：73

作者：

Cook, Peter F. ^{[1
,2
]}

Reichmuth, Colleen ^{[2
]}

Rouse, Andrew A. ^{[2
]}

Libby, Laura A. ^{[3
]}

Dennison, Sophie E. ^{[4
]}

Carmichael, Owen T. ^{[5
]}

Kruse-Elliott, Kris T. ^{[4
]}

Bloom, Josh ^{[4
]}

Singh, Baljeet ^{[3
]}

Fravel, Vanessa A. ^{[6
]}

Barbosa, Lorraine ^{[6
]}

Stuppino, Jim J. ^{[4
]}

Van Bonn, William G. ^{[7
]}

Gulland, Frances M. D. ^{[6
]}

Ranganath, Charan ^{[3
]}

机构：

[1] Emory Univ, Ctr Neuropolicy, Atlanta, GA 30322 USA

[2] Univ Calif Santa Cruz, Inst Marine Sci, Pinniped Cognit & Sensory Syst Lab, Santa Cruz, CA 95060 USA

[3] Univ Calif Davis, Dynam Memory Lab, Ctr Neurosci, Davis, CA 95618 USA

[4] AnimalScan Adv Vet Imaging, Redwood City, CA 94063 USA

[5] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA

[6] Marine Mammal Ctr, Sausalito, CA 94965 USA

[7] Shedd Aquarium, Chicago, IL 60605 USA

来源：

SCIENCE | 2015年 / 350卷 / 6267期

关键词：

DOMOIC ACID TOXICOSIS; ZALOPHUS-CALIFORNIANUS; LESIONS; CORTEX;

D O I：

10.1126/science.aac5675

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Domoic acid (DA) is a naturally occurring neurotoxin known to harm marine animals. DA-producing algal blooms are increasing in size and frequency. Although chronic exposure is known to produce brain lesions, the influence of DA toxicosis on behavior in wild animals is unknown. We showed, in a large sample of wild sea lions, that spatial memory deficits are predicted by the extent of right dorsal hippocampal lesions related to natural exposure to DA and that exposure also disrupts hippocampal-thalamic brain networks. Because sea lions are dynamic foragers that rely on flexible navigation, impaired spatial memory may affect survival in the wild.

引用

页码：1545 / 1547

页数：3

共 19 条

[1] FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI [J].