Michael addition of indoles to β-nitrostyrenes catalyzed by HY zeolite under solvent-free conditions

被引：30

作者：

Jeganathan, Mariappan ^{[1
]}

Kanagaraj, Kuppusamy ^{[1
]}

Dhakshinamoorthy, Amarajothi ^{[1
,2
]}

Pitchumani, Kasi ^{[1
,2
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Madurai 625021, Tamil Nadu, India

[2] Madurai Kamaraj Univ, Sch Chem, Ctr Green Chem Proc, Madurai 625021, Tamil Nadu, India

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 13期

关键词：

Michael addition; HY zeolite; Indole; beta-Nitrostyrenes; C-C bond formation; FRIEDEL-CRAFTS ALKYLATION; ELECTRON-DEFICIENT OLEFINS; ONE-POT SYNTHESIS; CONJUGATE ADDITION; HIGHLY EFFICIENT; LEWIS-ACIDS; NITROALKENES; NITROOLEFINS; DERIVATIVES; PYRROLE;

D O I：

10.1016/j.tetlet.2014.01.112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Michael addition of indoles to beta-nitrostyrenes is reported using HY zeolite as catalyst under mild reaction conditions. This methodology allows the synthesis of various indole derivatives in good to high yields at 50 C under solvent-free conditions. The short reaction time and achieving high yield of the desired products are the main advantages of the present work. The catalyst can be easily recovered and reused for six successive runs without considerable changes in yields. This Michael addition catalyzed by HY zeolite is operationally simple and can be considered as a greener protocol as it avoids the use of corrosive acids and toxic reagents. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：2061 / 2064

页数：4

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