Syntheses of fluorinated ligands to probe binding of antigenic determinants of Vibrio cholerae O:1, serotypes Inaba and Ogawa, to antibodies

被引：10

作者：

Chang, AHC

Horton, D

Kovác, P ^{[1
]}

机构：

[1] NIDDK, NIH, LMC, Bethesda, MD 20892 USA

[2] American Univ, Dept Chem, Washington, DC 20016 USA

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(99)00505-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Derivatives of methyl alpha-glycosides of antigenic determinants of Vibrio cholerae O:1, serotypes Inaba and Ogawa, specifically Fluorinated at position 2' or 4' have been synthesized by coupling the appropriately fluorinated derivatives of 3-deoxy-L-glycero-tetronic acid with the methyl oc-glycosides of perosamine. The compound having the fluorine atom at position 2 was obtained by electrophilic addition of fluorine to the glycal derived from the parent antigenic determinant, serotypes Inaba, using Selectfluor(TM) as a fluorination reagent. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：595 / 606

页数：12

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